Crosstalk of Cell Death Pathways Unveils an Autophagy-related Gene AOC3 As a Critical Prognostic Marker in Colorectal Cancer

Overview

Journal Commun Biol

Specialty Biology

Date 2024 Mar 9

PMID 38461356

Authors

Hui Xu

Haiyang Cui

Siyuan Weng

Yuyuan Zhang

Libo Wang

Zhe Xing

Xinwei Han

Zaoqu Liu

Affiliations

Soon will be listed here.

Abstract

The intricate crosstalk of various cell death forms was recently implicated in cancers, laying a foundation for exploring the association between cell death and cancers. Recent evidence has demonstrated that biological networks outperform snapshot gene expression profiles at discovering promising biomarkers or heterogenous molecular subtypes across different cancer types. In order to investigate the behavioral patterns of cell death-related interaction perturbation in colorectal cancer (CRC), this study constructed the interaction-perturbation network with 11 cell death pathways and delineated four cell death network (CDN) derived heterogeneous subtypes (CDN1-4) with distinct molecular characteristics and clinical outcomes. Specifically, we identified a subtype (CDN4) endowed with high autophagy activity and the worst prognosis. Furthermore, AOC3 was identified as a potential autophagy-related biomarker, which demonstrated exceptional predictive performance for CDN4 and significant prognostic value. Overall, this study sheds light on the complex interplay of various cell death forms and reveals an autophagy-related gene AOC3 as a critical prognostic marker in CRC.

Citing Articles

Integrated transcriptomics and metabolomics provide insights into the biosynthesis of militarine in the cell suspension culture system of Bletilla striata.

Li Q, Xu M, Wu F, Guo Z, Yang N, Li L Adv Biotechnol (Singap). 2025; 2(3):25.

PMID: 39883253 PMC: 11740853. DOI: 10.1007/s44307-024-00032-w.

The role of autophagy in pancreatic diseases.

Zhang W, Wu Q, Shao B Front Pharmacol. 2024; 15:1444657.

PMID: 39403146 PMC: 11471688. DOI: 10.3389/fphar.2024.1444657.

Cathepsin S Is More Abundant in Serum of subsp. -Infected Dairy Cows.

Duda H, von Toerne C, Korbonits L, Didier A, Scholz A, Martlbauer E Metabolites. 2024; 14(4).

PMID: 38668343 PMC: 11051907. DOI: 10.3390/metabo14040215.

References

Danaher P, Warren S, Lu R, Samayoa J, Sullivan A, Pekker I . Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA). J Immunother Cancer. 2018; 6(1):63. PMC: 6013904. DOI: 10.1186/s40425-018-0367-1. View

Rooney M, Shukla S, Wu C, Getz G, Hacohen N . Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 2015; 160(1-2):48-61. PMC: 4856474. DOI: 10.1016/j.cell.2014.12.033. View

Yarom N, Gresham G, Boame N, Jonker D . KRAS Status as a Predictor of Chemotherapy Activity in Patients With Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2019; 18(4):e309-e315. DOI: 10.1016/j.clcc.2019.05.004. View

Chaudhary N, Choudhary B, Shah S, Khapare N, Dwivedi N, Gaikwad A . Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. Int J Cancer. 2021; 149(7):1495-1511. DOI: 10.1002/ijc.33711. View

de Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij L . Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med. 2013; 19(5):614-8. DOI: 10.1038/nm.3174. View

Hoshida Y, Brunet J, Tamayo P, Golub T, Mesirov J . Subclass mapping: identifying common subtypes in independent disease data sets. PLoS One. 2007; 2(11):e1195. PMC: 2065909. DOI: 10.1371/journal.pone.0001195. View

Amaravadi R, Kimmelman A, Debnath J . Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discov. 2019; 9(9):1167-1181. PMC: 7306856. DOI: 10.1158/2159-8290.CD-19-0292. View

Karasaki T, Nagayama K, Kuwano H, Nitadori J, Sato M, Anraku M . An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer. J Thorac Oncol. 2017; 12(5):791-803. DOI: 10.1016/j.jtho.2017.01.005. View

OConnell E, Reynolds I, McNamara D, Burke J, Prehn J . Resistance to Cell Death in Mucinous Colorectal Cancer-A Review. Cancers (Basel). 2021; 13(6). PMC: 8003305. DOI: 10.3390/cancers13061389. View

10.

Tan Y, Chen Q, Li X, Zeng Z, Xiong W, Li G . Pyroptosis: a new paradigm of cell death for fighting against cancer. J Exp Clin Cancer Res. 2021; 40(1):153. PMC: 8091792. DOI: 10.1186/s13046-021-01959-x. View

11.

Hoshida Y . Nearest template prediction: a single-sample-based flexible class prediction with confidence assessment. PLoS One. 2010; 5(11):e15543. PMC: 2990751. DOI: 10.1371/journal.pone.0015543. View

12.

Huang X, Zhang X, Bai X, Liang T . Eating self for not be eaten: Pancreatic cancer suppresses self-immunogenicity by autophagy-mediated MHC-I degradation. Signal Transduct Target Ther. 2020; 5(1):94. PMC: 7293222. DOI: 10.1038/s41392-020-0209-8. View

13.

Chretien S, Zerdes I, Bergh J, Matikas A, Foukakis T . Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy. Cancers (Basel). 2019; 11(5). PMC: 6562626. DOI: 10.3390/cancers11050628. View

14.

Khan M, Zubair H, Anand S, Srivastava S, Singh S, Singh A . Dysregulation of metabolic enzymes in tumor and stromal cells: Role in oncogenesis and therapeutic opportunities. Cancer Lett. 2020; 473:176-185. PMC: 7067140. DOI: 10.1016/j.canlet.2020.01.003. View

15.

Li Y, Hung J, Yu T, Liou J, Wei J, Kao H . Serum vascular adhesion protein-1 predicts all-cause mortality and cancer-related mortality in subjects with colorectal cancer. Clin Chim Acta. 2013; 428:51-6. DOI: 10.1016/j.cca.2013.10.024. View

16.

Grandison S, Morris R . Biological pathway kinetic rate constants are scale-invariant. Bioinformatics. 2008; 24(6):741-3. DOI: 10.1093/bioinformatics/btn041. View

17.

Marisa L, De Reynies A, Duval A, Selves J, Gaub M, Vescovo L . Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med. 2013; 10(5):e1001453. PMC: 3660251. DOI: 10.1371/journal.pmed.1001453. View

18.

Guinney J, Dienstmann R, Wang X, De Reynies A, Schlicker A, Soneson C . The consensus molecular subtypes of colorectal cancer. Nat Med. 2015; 21(11):1350-6. PMC: 4636487. DOI: 10.1038/nm.3967. View

19.

Mermel C, Schumacher S, Hill B, Meyerson M, Beroukhim R, Getz G . GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 2011; 12(4):R41. PMC: 3218867. DOI: 10.1186/gb-2011-12-4-r41. View

20.

Pages F, Mlecnik B, Marliot F, Bindea G, Ou F, Bifulco C . International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018; 391(10135):2128-2139. DOI: 10.1016/S0140-6736(18)30789-X. View