Effects of Short-term Preoperative Intranasal Dexmedetomidine Plus Conventional Treatment on Delirium Following Cardiac Surgery in Patients with Sleep Disorders

Overview

Journal Perioper Med (Lond)

Publisher Biomed Central

Date 2024 Mar 9

PMID 38461276

Authors

Jun Fang

Jia Yang

Mingyu Zhai

Qiong Zhang

Min Zhang

Yanhu Xie

Affiliations

Soon will be listed here.

Abstract

Study Objectives: To assess whether preoperative dexmedetomidine (DEX) nasal drips combined with conventional treatment could mitigate the occurrence of postoperative delirium (POD).

Design: A prospective randomised controlled study.

Setting: The cardiac surgery intensive care unit (CSICU) and patient hospitalisation ward at a university hospital.

Participants: A total of 100 patients (aged ≥60 years) undergoing cardiac surgery at a university hospital between 7 January 2022, and 30 November 2022 met the eligibility criteria and were included in the study.

Interventions: Patients with sleep disorders (Pittsburgh Sleep Quality Index ≥8) were divided into two groups: Group A (the placebo group, n=50), receiving a short-term preoperative placebo combined with conventional treatment and Group B (the DEX group, n=50), receiving short-term preoperative DEX combined with conventional treatment.

Measurements And Results: The Confusion Assessment Method for the ICU (CAM-ICU) was used for POD assessment in the CSICU, while the CAM was employed to assess delirium in the patient ward. Group B demonstrated a reduced incidence of POD compared to Group A (12% vs. 30%, odds ratio: 0.318, 95% confidence interval: 0.112-0.905, p=0.027).

Conclusion: The combined treatment involving DEX demonstrated a decreased incidence of POD in elderly individuals with sleep disorders undergoing cardiac surgery compared to the placebo combination treatment.

Trial Registration: URL: www.chictr.org.cn with registration number ChiCTR 2100043968, registered on 06/03/2021.

Citing Articles

Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials.

Meng C, Wang D, Zhao Y, Sun J, Miao G, Chen L J Cardiothorac Surg. 2025; 20(1):110.

PMID: 39891182 PMC: 11783797. DOI: 10.1186/s13019-025-03360-7.

Latent profiles and determinants of postoperative sleep quality in elective surgery patients.

Yang B, Li J, Feng D, Gong J, Yang Y, Cai X Sci Rep. 2025; 15(1):617.

PMID: 39753664 PMC: 11698858. DOI: 10.1038/s41598-024-84896-x.

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