Risk Factors for Electrical Storms Following Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction: A Meta-analysis

Overview

Journal Biomol Biomed

Specialties Biochemistry
General Medicine

Date 2024 Mar 9

PMID 38460169

Authors

Xiao Xiong

Qiang Ye

Yongquan Peng

Affiliations

Soon will be listed here.

Abstract

Electrical storms (ESs) following percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients pose a significant challenge, affecting prognostic outcomes and increasing mortality. This meta-analysis synthesized data from 11 studies involving 9,666 AMI patients to identify risk factors associated with ES following PCI. Our findings revealed an average ES incidence of 7.70%, with identified risk factors including low thrombolysis in myocardial infarction (TIMI) flow grades (0-1), elevated cardiac troponin I levels, persistent hypotension, reperfusion arrhythmias, the right coronary artery being the infarct-related artery, increased diameter of the infarct-related artery, renal dysfunction, elevated creatine kinase-MB, and bradycardia. Notably, the use of β-blockers was found to significantly reduce the risk of ES. The study underscores the importance of early identification and management of these risk factors in AMI patients undergoing PCI to prevent the occurrence of ES, highlighting the protective role of β-blockers. This research provides a foundation for future strategies aimed at reducing the incidence and improving the prognosis of ES in this patient population.

Citing Articles

Establishment and application of an intraoperative reperfusion arrhythmia prediction model for PCI in elderly patients with acute coronary syndrome.

Qin Z, Fu L, Gou Q, Yang Y, He L Am J Transl Res. 2024; 16(11):6447-6456.

PMID: 39678573 PMC: 11645595. DOI: 10.62347/JMBY1770.

References

Peet C, Ivetic A, Bromage D, Shah A . Cardiac monocytes and macrophages after myocardial infarction. Cardiovasc Res. 2019; 116(6):1101-1112. PMC: 7177720. DOI: 10.1093/cvr/cvz336. View

Li Q, Li Z, Fan Z, Yang Y, Lu C . Involvement of non‑coding RNAs in the pathogenesis of myocardial ischemia/reperfusion injury (Review). Int J Mol Med. 2021; 47(4). PMC: 7895537. DOI: 10.3892/ijmm.2021.4875. View

Dyer S, Mogni B, Gottlieb M . Electrical storm: A focused review for the emergency physician. Am J Emerg Med. 2020; 38(7):1481-1487. DOI: 10.1016/j.ajem.2020.04.017. View

Piccirillo G, Moscucci F, Persi A, Di Barba D, Pappada M, Rossi P . Intra-QT spectral coherence as a possible noninvasive marker of sustained ventricular tachycardia. Biomed Res Int. 2014; 2014:583035. PMC: 4123476. DOI: 10.1155/2014/583035. View

Cheang S, Lelorier P, Gajewski K . Diffuse ST-Segment Elevation With Idiopathic Malignant Ventricular Arrhythmia. Circulation. 2021; 144(5):399-402. DOI: 10.1161/CIRCULATIONAHA.121.054910. View

Elsokkari I, Sapp J . Electrical storm: Prognosis and management. Prog Cardiovasc Dis. 2021; 66:70-79. DOI: 10.1016/j.pcad.2021.06.007. View

Raman S, Chandrashekhar Y . Substrate for Ventricular Arrhythmia: To See Is to Know?. JACC Cardiovasc Imaging. 2020; 13(2 Pt 1):532-534. DOI: 10.1016/j.jcmg.2020.01.002. View

Mehta R, Starr A, Lopes R, Hochman J, Widimsky P, Pieper K . Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention. JAMA. 2009; 301(17):1779-89. DOI: 10.1001/jama.2009.600. View

Looi K, Tang A, Agarwal S . Ventricular arrhythmia storm in the era of implantable cardioverter-defibrillator. Postgrad Med J. 2015; 91(1079):519-26. DOI: 10.1136/postgradmedj-2015-133550. View

10.

Zhou P, Yang X, Yang D, Jiang X, Wang W, Yue R . Integrin-Linked Kinase Activation Prevents Ventricular Arrhythmias Induced by Ischemia/Reperfusion Via Inhibition of Connexin 43 Remodeling. J Cardiovasc Transl Res. 2020; 14(4):610-618. PMC: 8397684. DOI: 10.1007/s12265-020-09979-2. View

11.

Laksman Z, Barichello S, Roston T, Deyell M, Krahn A . Acute Management of Ventricular Arrhythmia in Patients With Suspected Inherited Heart Rhythm Disorders. JACC Clin Electrophysiol. 2019; 5(3):267-283. DOI: 10.1016/j.jacep.2019.02.001. View

12.

Watanabe M, Yokoshiki H, Noda T, Yokota I, Nitta T, Aizawa Y . Electrical Storm as an Independent Mortality Risk in Patients with Preserved or Moderately Reduced Left Ventricular Function. Int Heart J. 2021; 62(6):1249-1256. DOI: 10.1536/ihj.20-832. View

13.

Henry T, Jollis J . Lessons Learned From Acute Myocardial Infarction Care in China. JAMA Netw Open. 2020; 3(10):e2021768. DOI: 10.1001/jamanetworkopen.2020.21768. View

14.

Sesselberg H, Moss A, McNitt S, Zareba W, Daubert J, Andrews M . Ventricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: a MADIT-II substudy. Heart Rhythm. 2007; 4(11):1395-402. DOI: 10.1016/j.hrthm.2007.07.013. View

15.

Pelliccia F, Greco C, Tanzilli G, Viceconte N, Schiariti M, Gaudio C . Long-term outcome of patients with ST-segment elevation myocardial infarction treated with low-dose intracoronary thrombolysis during primary percutaneous coronary intervention: the 5-year results of the DISSOLUTION Trial. J Thromb Thrombolysis. 2020; 51(1):212-216. DOI: 10.1007/s11239-020-02157-w. View

16.

Deng H, Shantsila A, Guo P, Zhan X, Fang X, Liao H . Multiple biomarkers and arrhythmia outcome following catheter ablation of atrial fibrillation: The Guangzhou Atrial Fibrillation Project. J Arrhythm. 2018; 34(6):617-625. PMC: 6288553. DOI: 10.1002/joa3.12111. View

17.

Gallone G, Magnoni M, Vergani V, Ceriotti F, Angeloni G, Scarano P . Short-term prognosis of unstable angina in the era of high-sensitivity cardiac troponin: insights for early rule-out strategies. Coron Artery Dis. 2020; 31(8):687-693. DOI: 10.1097/MCA.0000000000000906. View

18.

Carubbi C, Masselli E, Pozzi G, Mattioli M, Martini S, Goldoni M . Combination of Platelet expression of PKCepsilon and cardiac troponin-I for early diagnosis of chest pain patients in the emergency department. Sci Rep. 2019; 9(1):2125. PMC: 6375996. DOI: 10.1038/s41598-019-38624-5. View

19.

Mont L, Cinca J, Blanch P, Blanco J, Figueras J, Brotons C . Predisposing factors and prognostic value of sustained monomorphic ventricular tachycardia in the early phase of acute myocardial infarction. J Am Coll Cardiol. 1996; 28(7):1670-6. DOI: 10.1016/S0735-1097(96)00383-X. View

20.

Hoole S, Bambrough P . Recent advances in percutaneous coronary intervention. Heart. 2020; 106(18):1380-1386. DOI: 10.1136/heartjnl-2019-315707. View