The Role of Pyroptosis in Viral Infection

Overview

Journal Arch Virol

Specialty Microbiology

Date 2024 Mar 8

PMID 38456965

Authors

Zhen Zhao

Yan Zhang

Bing Luo

Affiliations

Soon will be listed here.

Abstract

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death, which is an important natural immune response. Pyroptosis plays a major role in combating pathogenic infections. The mechanism of pyroptosis is distinct from other forms of cell death and is characterized by its dependence on inflammatory caspases (mainly caspases 1, 4, 5, and 11). Activation of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory vesicles is involved in caspase-1 activation and cleavage, which in turn triggers cleavage and multimerization of multiple gasdermin family members, including gasdermin-D (GSDMD). This further leads to cell perforation and cellular distension, causing cell membrane rupture, resulting in a massive efflux of cell contents, which triggers inflammatory reactions. In recent years, detailed study of viral diseases, has demonstrated that pyroptosis is closely associated with the development of viral diseases. This article focuses on the mechanism of pyroptosis and the connection between pyroptosis and viral infection.

References

Verburg S, Lelievre R, Westerveld M, Inkol J, Sun Y, Workenhe S . Viral-mediated activation and inhibition of programmed cell death. PLoS Pathog. 2022; 18(8):e1010718. PMC: 9371342. DOI: 10.1371/journal.ppat.1010718. View

Galluzzi L, Vitale I, Abrams J, Alnemri E, Baehrecke E, Blagosklonny M . Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2011; 19(1):107-20. PMC: 3252826. DOI: 10.1038/cdd.2011.96. View

Ketelut-Carneiro N, Fitzgerald K . Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die. J Mol Biol. 2021; 434(4):167378. DOI: 10.1016/j.jmb.2021.167378. View

Tang D, Kang R, Vanden Berghe T, Vandenabeele P, Kroemer G . The molecular machinery of regulated cell death. Cell Res. 2019; 29(5):347-364. PMC: 6796845. DOI: 10.1038/s41422-019-0164-5. View

Chen Y, Smith M, Thirumalai K, Zychlinsky A . A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J. 1996; 15(15):3853-60. PMC: 452076. View

Miao E, Leaf I, Treuting P, Mao D, Dors M, Sarkar A . Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol. 2010; 11(12):1136-42. PMC: 3058225. DOI: 10.1038/ni.1960. View

Cookson B, Brennan M . Pro-inflammatory programmed cell death. Trends Microbiol. 2001; 9(3):113-4. DOI: 10.1016/s0966-842x(00)01936-3. View

Siegel R . Caspases at the crossroads of immune-cell life and death. Nat Rev Immunol. 2006; 6(4):308-17. DOI: 10.1038/nri1809. View

Vanaja S, Russo A, Behl B, Banerjee I, Yankova M, Deshmukh S . Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Cell. 2016; 165(5):1106-1119. PMC: 4874922. DOI: 10.1016/j.cell.2016.04.015. View

10.

Yazdi A, Guarda G, DOmbrain M, Drexler S . Inflammatory caspases in innate immunity and inflammation. J Innate Immun. 2010; 2(3):228-37. DOI: 10.1159/000283688. View

11.

Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X . Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020; 180(5):941-955.e20. DOI: 10.1016/j.cell.2020.02.002. View

12.

Doitsh G, Greene W . Dissecting How CD4 T Cells Are Lost During HIV Infection. Cell Host Microbe. 2016; 19(3):280-91. PMC: 4835240. DOI: 10.1016/j.chom.2016.02.012. View

13.

Man S, Karki R, Kanneganti T . Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev. 2017; 277(1):61-75. PMC: 5416822. DOI: 10.1111/imr.12534. View

14.

Liu X, Zhang Z, Ruan J, Pan Y, Magupalli V, Wu H . Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016; 535(7610):153-8. PMC: 5539988. DOI: 10.1038/nature18629. View

15.

Li L, Zhang Z, Zhou W, Chen J, Jin H, Fang H . Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects. Biomed Pharmacother. 2021; 130:110641. PMC: 7437484. DOI: 10.1016/j.biopha.2020.110641. View

16.

Vande Walle L, Lamkanfi M . Pyroptosis. Curr Biol. 2016; 26(13):R568-R572. DOI: 10.1016/j.cub.2016.02.019. View

17.

Chen S, Mei S, Luo Y, Wu H, Zhang J, Zhu J . Gasdermin Family: a Promising Therapeutic Target for Stroke. Transl Stroke Res. 2018; 9(6):555-563. DOI: 10.1007/s12975-018-0666-3. View

18.

Feng S, Fox D, Man S . Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death. J Mol Biol. 2018; 430(18 Pt B):3068-3080. DOI: 10.1016/j.jmb.2018.07.002. View

19.

Ge X, Chen J, Li L, Ding P, Wang Q, Zhang W . Midostaurin potentiates rituximab antitumor activity in Burkitt's lymphoma by inducing apoptosis. Cell Death Dis. 2018; 10(1):8. PMC: 6315025. DOI: 10.1038/s41419-018-1259-5. View

20.

Brunette R, Young J, Whitley D, Brodsky I, Malik H, Stetson D . Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. J Exp Med. 2012; 209(11):1969-83. PMC: 3478938. DOI: 10.1084/jem.20121960. View