Identification and Evaluation of Antimicrobial and Anti-arthritis Activities of Hydroethanolic Extract of Rubus Ellipticus Leaves

Overview

Journal Narra J

Specialties Public Health
Tropical Medicine

Date 2024 Mar 8

PMID 38455614

Authors

Anjana Kumari

Vinit Prakash

Dinesh Gupta

Lokender Kashyap

Rajat Goyal

Hitesh Chopra

Rupesh K Gautam

Sandip Chakraborty

Deepak Chandran

Kuldeep Dhama

Affiliations

Soon will be listed here.

Abstract

is a native plant to India's tropical and subtropical regions and has been used as a traditional medicinal. The aim of study was to identify and evaluate the antimicrobial and anti-arthritis activities of hydroethanolic extract of leaves (HEERE). The leaves were collected from the Narkanda Valley, India and were shade-dried and finely ground to produce the powder. The hydroethanolic extract was utilized for phytochemical analysis to determine the existence of carbohydrate, phenolic, terpenoid, flavonoid, saponin, glycoside, tannin, protein, and alkaloid. The HEERE was futher analyzed by gas chromatography-mass spectrometry (GC-MS) for the characterization of the phytoconstituents. The antimicrobial activity was tested against as well as . To assess its anti-arthritic activities, different doses of HEERE were given orally to complete Freund's adjuvant (CFA)-induced albino Wistar rats for twenty-one days. The GC-MS analysis of hydroethanolic extracts from leaves detected and identified the presence of 33 phytochemical compounds. HEERE showed significant effects against , and strains at 600 ppm. Our data indicated that HEERE 200 mg/kg was more effective than 50 mg/kg as anti-arthritis. Paw volume, ankle-joint diameter, the number leucocytes, and erythrocyte sedimentation rate (ESR) were all significantly reduced in experimental rats. Furthermore, when compared to respective standard drugs, the body weight, erythrocyte, hemoglobin, and synobium healing effect have all improved. These data demonstrated the potential of for the long-term investigation of antimicrobial and anti-arthritic properties.

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