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Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles

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Date 2024 Mar 8
PMID 38455104
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Abstract

Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

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References
1.
Jaks V, Barker N, Kasper M, van Es J, Snippert H, Clevers H . Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 2008; 40(11):1291-9. DOI: 10.1038/ng.239. View

2.
Vidal V, Chaboissier M, Lutzkendorf S, Cotsarelis G, Mill P, Hui C . Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol. 2005; 15(15):1340-51. DOI: 10.1016/j.cub.2005.06.064. View

3.
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lonnerberg P . Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity. Cell Syst. 2016; 3(3):221-237.e9. PMC: 5052454. DOI: 10.1016/j.cels.2016.08.010. View

4.
Nowak J, Polak L, Pasolli H, Fuchs E . Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell. 2008; 3(1):33-43. PMC: 2877596. DOI: 10.1016/j.stem.2008.05.009. View

5.
Yu N, Hu T, Yang H, Zhang L, Zhu L, Zhou X . Androgen receptor inhibits the hair follicle induction potential of dermal papilla cells by binding with Tcf4 at the A574 binding site. Genes Dis. 2023; 10(1):51-54. PMC: 10066252. DOI: 10.1016/j.gendis.2022.04.015. View