Mitochondrial Dysfunction Route As a Possible Biomarker and Therapy Target for Human Cancer

Overview

Journal Biomed J

Publisher Elsevier

Specialty General Medicine

Date 2024 Mar 7

PMID 38452973

Authors

Rawan Al-Faze

Hoda A Ahmed

Mohamed A El-Atawy

Hayat Zagloul

Eida M Alshammari

Mariusz Jaremko

Abdul-Hamid Emwas

Gehan M Nabil

Demiana H Hanna

Affiliations

Soon will be listed here.

Abstract

Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. Their dysregulated activities have been associated with the growth and metastasis of different kinds of human cancer, particularly ovarian carcinoma. In this review, we briefly demonstrated the modified mitochondrial function in cancer, including mutations in mitochondrial DNA (mtDNA), reactive oxygen species (ROS) production, dynamics, apoptosis of cells, autophagy, and calcium excess to maintain cancer genesis, progression, and metastasis. Furthermore, the mitochondrial dysfunction pathway for some genomic, proteomic, and metabolomics modifications in ovarian cancer has been studied. Additionally, ovarian cancer has been linked to targeted therapies and biomarkers found through various alteration processes underlying mitochondrial dysfunction, notably targeting (ROS), metabolites, rewind metabolic pathways, and chemo-resistant ovarian carcinoma cells.

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