Associations Between the Platelet/high-density Lipoprotein Cholesterol Ratio and Likelihood of Nephrolithiasis: a Cross-sectional Analysis in United States Adults

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 Mar 7

PMID 38449847

Authors

Junjie Ni

Lin Lv

Pu Wu

Chaoyang Xu

Affiliations

Soon will be listed here.

Abstract

Aims: The primary objective of this study was to investigate the relationship between the platelet/high-density lipoprotein cholesterol ratio (PHR) and the prevalence of nephrolithiasis within the adult population of the United States.

Methods: The data used in this study were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. The analysis included a non-pregnant population aged 20 years or older, providing proper PHR index and nephrolithiasis data. The research utilized subgroup analyses and weighted univariate and multivariable logistic regression to evaluate the independent association between the PHR and the susceptibility to nephrolithiasis.

Results: The study comprised 30,899 participants with an average PHR value of 19.30 ± 0.11. The overall prevalence rate of nephrolithiasis was estimated at 9.98% with an increase in the higher PHR tertiles (T1, 8.49%; T2, 10.11%; T3, 11.38%, < 0.0001). An elevated PHR level was closely linked with a higher susceptibility to nephrolithiasis. Compared with patients in T1, and after adjusting for potential confounders in model 2, the corresponding odds ratio for nephrolithiasis in T3 was 1.48 (95% CI: 1.06 to 2.08), with a -value = 0.02. The results of the interaction tests revealed a significant impact of chronic kidney disease on the relationship between PHR and nephrolithiasis. Furthermore, the restricted cubic spline analyses exhibited a positive, non-linear correlation between PHR and the risk of nephrolithiasis.

Conclusion: A convenient biomarker, the PHR, was independently associated with nephrolithiasis and could be a novel biomarker in predicting occurrence in clinical decision.

Citing Articles

Association between platelet/high-density lipoprotein cholesterol ratio and blood eosinophil counts in American adults with asthma: a population-based study.

Zhao Q, Yang P, Li J, Du L, Wang W, Zhu S Lipids Health Dis. 2025; 24(1):67.

PMID: 39984961 PMC: 11846263. DOI: 10.1186/s12944-025-02479-9.

Platelet to high density lipoprotein cholesterol ratio is associated with diabetes and prediabetes in NHANES 2005 to 2018.

Chen P, Zhu M, Guo M, Shi D, Chen Z, Du J Sci Rep. 2024; 14(1):30082.

PMID: 39627414 PMC: 11614884. DOI: 10.1038/s41598-024-81637-y.

Associations of Platelet to High-Density Lipoprotein Cholesterol Ratio with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study from the US National Health and Nutrition Examination Survey.

Wang Y, Long X, Tan M, Song X Int J Chron Obstruct Pulmon Dis. 2024; 19:2321-2332.

PMID: 39465032 PMC: 11512790. DOI: 10.2147/COPD.S481197.

Association between platelet to high-density lipoprotein cholesterol ratio (PHR) and hypertension: evidence from NHANES 2005-2018.

Chen J, Wang B, Liu C, Li C, Meng T, Wang J Lipids Health Dis. 2024; 23(1):346.

PMID: 39462374 PMC: 11514891. DOI: 10.1186/s12944-024-02342-3.

Association of platelet-to-HDL cholesterol ratio with frailty and all-cause mortality.

Zhang J, Chen L, Zhang H Lipids Health Dis. 2024; 23(1):344.

PMID: 39443978 PMC: 11515673. DOI: 10.1186/s12944-024-02329-0.

References

Weinberg A, Patel C, Chertow G, Leppert J . Diabetic severity and risk of kidney stone disease. Eur Urol. 2013; 65(1):242-7. PMC: 3866968. DOI: 10.1016/j.eururo.2013.03.026. View

Ferraro P, Curhan G . Serum Uric Acid and Risk of Kidney Stones. Am J Kidney Dis. 2017; 70(2):158-159. DOI: 10.1053/j.ajkd.2017.05.004. View

Kittanamongkolchai W, Vaughan L, Enders F, Dhondup T, Mehta R, Krambeck A . The Changing Incidence and Presentation of Urinary Stones Over 3 Decades. Mayo Clin Proc. 2018; 93(3):291-299. PMC: 5849397. DOI: 10.1016/j.mayocp.2017.11.018. View

Jialal I, Jialal G, Adams-Huet B . The platelet to high density lipoprotein -cholesterol ratio is a valid biomarker of nascent metabolic syndrome. Diabetes Metab Res Rev. 2020; 37(6):e3403. DOI: 10.1002/dmrr.3403. View

Lee H, Jeong S, Park M, Linnes M, Han H, Kim J . Gallotannin suppresses calcium oxalate crystal binding and oxalate-induced oxidative stress in renal epithelial cells. Biol Pharm Bull. 2012; 35(4):539-44. PMC: 3910304. DOI: 10.1248/bpb.35.539. View

Levey A, Stevens L, Schmid C, Zhang Y, Castro 3rd A, Feldman H . A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150(9):604-12. PMC: 2763564. DOI: 10.7326/0003-4819-150-9-200905050-00006. View

Wang K, Ge J, Han W, Wang D, Zhao Y, Shen Y . Risk factors for kidney stone disease recurrence: a comprehensive meta-analysis. BMC Urol. 2022; 22(1):62. PMC: 9017041. DOI: 10.1186/s12894-022-01017-4. View

Maddahi N, Yarizadeh H, Aghamir S, Alizadeh S, Yekaninejad M, Mirzaei K . The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis. BMC Res Notes. 2020; 13(1):373. PMC: 7414556. DOI: 10.1186/s13104-020-05206-y. View

Tsujihata M, Momohara C, Yoshioka I, Tsujimura A, Nonomura N, Okuyama A . Atorvastatin inhibits renal crystal retention in a rat stone forming model. J Urol. 2008; 180(5):2212-7. DOI: 10.1016/j.juro.2008.07.024. View

10.

Di X, Liu S, Xiang L, Jin X . Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018. Front Immunol. 2023; 14:1116224. PMC: 9989007. DOI: 10.3389/fimmu.2023.1116224. View

11.

Ciardullo S, Monti T, Perseghin G . Prevalence of Liver Steatosis and Fibrosis Detected by Transient Elastography in Adolescents in the 2017-2018 National Health and Nutrition Examination Survey. Clin Gastroenterol Hepatol. 2020; 19(2):384-390.e1. DOI: 10.1016/j.cgh.2020.06.048. View

12.

Zhang C, Qiu S, Bian H, Tian B, Wang H, Tu X . Association between Dietary Inflammatory Index and kidney stones in US adults: data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Public Health Nutr. 2021; 24(18):6113-6121. PMC: 11148609. DOI: 10.1017/S1368980021000793. View

13.

Ciardullo S, Perseghin G . Statin use is associated with lower prevalence of advanced liver fibrosis in patients with type 2 diabetes. Metabolism. 2021; 121:154752. DOI: 10.1016/j.metabol.2021.154752. View

14.

Torricelli F, De S, Gebreselassie S, Li I, Sarkissian C, Monga M . Dyslipidemia and kidney stone risk. J Urol. 2013; 191(3):667-72. DOI: 10.1016/j.juro.2013.09.022. View

15.

Ferraro P, Taylor E, Eisner B, Gambaro G, Rimm E, Mukamal K . History of kidney stones and the risk of coronary heart disease. JAMA. 2013; 310(4):408-15. PMC: 4019927. DOI: 10.1001/jama.2013.8780. View

16.

Geiss L, Wang J, Cheng Y, Thompson T, Barker L, Li Y . Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980-2012. JAMA. 2014; 312(12):1218-26. DOI: 10.1001/jama.2014.11494. View

17.

Zou B, Yeo Y, Nguyen V, Cheung R, Ingelsson E, Nguyen M . Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999-2016. J Intern Med. 2020; 288(1):139-151. DOI: 10.1111/joim.13069. View

18.

Taguchi K, Okada A, Hamamoto S, Unno R, Moritoki Y, Ando R . M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development. Sci Rep. 2016; 6:35167. PMC: 5059697. DOI: 10.1038/srep35167. View

19.

Thongprayoon C, Krambeck A, Rule A . Determining the true burden of kidney stone disease. Nat Rev Nephrol. 2020; 16(12):736-746. DOI: 10.1038/s41581-020-0320-7. View

20.

Vilar-Gomez E, Nephew L, Vuppalanchi R, Gawrieh S, Mladenovic A, Pike F . High-quality diet, physical activity, and college education are associated with low risk of NAFLD among the US population. Hepatology. 2021; 75(6):1491-1506. DOI: 10.1002/hep.32207. View