» Articles » PMID: 38449844

Insulin Resistance in NSCLC: Unraveling the Link Between Development, Diagnosis, and Treatment

Overview
Specialty Endocrinology
Date 2024 Mar 7
PMID 38449844
Authors
Affiliations
Soon will be listed here.
Abstract

Lung cancer is responsible for the highest number of cancer-related deaths, with non-small cell lung cancer (NSCLC) being the most prevalent subtype. A critical aspect of managing lung cancer is reducing morbidity and mortality rates among NSCLC patients. Identifying high-risk factors for lung cancer and facilitating early diagnosis are invaluable in achieving this objective. Recent research has highlighted the association between insulin resistance and the development of NSCLC, further emphasizing its significance in the context of lung cancer. It has been discovered that improving insulin resistance can potentially inhibit the progression of lung cancer. Consequently, this paper aims to delve into the occurrence of insulin resistance, the mechanisms underlying its involvement in lung cancer development, as well as its potential value in predicting, assessing, and treating lung cancer.

Citing Articles

Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis.

Yu X, Fu B, Sun T, Sun X Front Genet. 2024; 15:1449881.

PMID: 39655224 PMC: 11625780. DOI: 10.3389/fgene.2024.1449881.


[Progress in the Study of Mechanisms Clinically Relevant to Insulin Resistance 
and Lung Cancer].

Chen X, Chen P Zhongguo Fei Ai Za Zhi. 2024; 27(10):755-762.

PMID: 39631832 PMC: 11629090. DOI: 10.3779/j.issn.1009-3419.2024.106.27.

References
1.
Li Z, Zhang H . Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression. Cell Mol Life Sci. 2015; 73(2):377-92. PMC: 11108301. DOI: 10.1007/s00018-015-2070-4. View

2.
Randle P, Garland P, Hales C, Newsholme E . The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963; 1(7285):785-9. DOI: 10.1016/s0140-6736(63)91500-9. View

3.
Yu J, Zhang L, Peng J, Ward R, Hao P, Wang J . Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways. Biochem Pharmacol. 2021; 195:114864. DOI: 10.1016/j.bcp.2021.114864. View

4.
Semple R, Sleigh A, Murgatroyd P, Adams C, Bluck L, Jackson S . Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. J Clin Invest. 2009; 119(2):315-22. PMC: 2631303. DOI: 10.1172/JCI37432. View

5.
ArulJothi K, Kumaran K, Senthil S, Nidhu A, Munaff N, Janitri V . Implications of reactive oxygen species in lung cancer and exploiting it for therapeutic interventions. Med Oncol. 2022; 40(1):43. PMC: 9734980. DOI: 10.1007/s12032-022-01900-y. View