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Stem Cell-Based Approaches in Parkinson's Disease Research

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Date 2024 Mar 7
PMID 38449089
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Abstract

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. While current treatments provide limited relief, they don't alter disease progression. Stem cell technology, involving patient-specific stem cell-derived neurons, offers a promising avenue for research and personalized regenerative therapies. This article reviews the potential of stem cell-based research in PD, summarizing ongoing efforts, their limitations, and introducing innovative research models. The integration of stem cell technology and advanced models promises to enhance our understanding and treatment strategies for PD.

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References
1.
Becerra-Calixto A, Mukherjee A, Ramirez S, Sepulveda S, Sinha T, Al-Lahham R . Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson's Disease Patient. Cells. 2023; 12(4). PMC: 9954141. DOI: 10.3390/cells12040625. View

2.
Polymeropoulos M, Lavedan C, Leroy E, Ide S, Dehejia A, Dutra A . Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997; 276(5321):2045-7. DOI: 10.1126/science.276.5321.2045. View

3.
Zhao M, Momma S, Delfani K, Carlen M, Cassidy R, Johansson C . Evidence for neurogenesis in the adult mammalian substantia nigra. Proc Natl Acad Sci U S A. 2003; 100(13):7925-30. PMC: 164689. DOI: 10.1073/pnas.1131955100. View

4.
Kim T, Piao J, Koo S, Kriks S, Chung S, Betel D . Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021; 28(2):343-355.e5. PMC: 8006469. DOI: 10.1016/j.stem.2021.01.005. View

5.
Henderson M, Trojanowski J, Lee V . α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies. Neurosci Lett. 2019; 709:134316. PMC: 7014913. DOI: 10.1016/j.neulet.2019.134316. View