Fully Bioresorbable Hybrid Opto-electronic Neural Implant System for Simultaneous Electrophysiological Recording and Optogenetic Stimulation

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Mar 6

PMID 38448437

Authors

Myeongki Cho

Jeong-Kyu Han

Jungmin Suh

Jeong Jin Kim

Jae Ryun Ryu

In Sik Min

Mingyu Sang

Selin Lim

Tae Soo Kim

Kyubeen Kim

Kyowon Kang

Kyuhyun Hwang

Kanghwan Kim

Eun-Bin Hong

Min-Ho Nam

Jongbaeg Kim

Young Min Song

Gil Ju Lee

Il-Joo Cho

Ki Jun Yu

Affiliations

Soon will be listed here.

Abstract

Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants. In this study, we introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The flexible and soft device, composed of biodegradable materials, has a direct optical and electrical interface with the curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized to minimize light transmission losses and photoelectric artifact interference, the device was chronically implanted in the brain of transgenic mice and performed to photo-stimulate the somatosensory area while recording local field potentials. Thus, the presented hybrid neural implant system, comprising biodegradable materials, promises to provide monitoring and therapy modalities for versatile applications in biomedicine.

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