MTA As Modulator of Periapical Tissue Healing in Rat Molar: A Histological Study

Overview

Journal J Oral Biol Craniofac Res

Publisher Elsevier

Date 2024 Mar 6

PMID 38445049

Authors

Christian Khoswanto

Ira Kusuma Dewi

Affiliations

Soon will be listed here.

Abstract

Background: Periapical surgery has been suggested as a treatment option for teeth with periapical lesions when those lesions continue despite receiving root canal therapy. Since sealing the apical region is the operation's primary goal, the choice of the root-end filling material affects how the surgery turns out. The retrofilling materials Zinc Oxide Eugenol (ZOE) and Mineral trioxide aggregate (MTA) are both known to have antibacterial characteristics. The purpose of this study is to determine how MTA affects as a Modulator of Periapical Tissue Healing through histological examination in Rat Molar.

Methods: A dental fissure bur measuring 0.7 mm is used to remove the buccal root apex from the buccal alveolar bone's surface, creating the cavity. One of the following is placed within each cavity: Group 1: MTA, Group 2: ZOE. For each material series, six samples were used. We classified the healing outcomes for each MTA and ZOE retrograde filling material into three groups based on histological analysis: the amount of newly generated bone, the number of fibroblasts, and the infiltration of neutrophils into the surgical site.

Results: On the 6th day of examination, fibroblasts were seen in the area around the wound. A significant inflammatory response, including neutrophil infiltration, was seen around the ZOE after retrograde filling. On the 16th day, the new alveolar bone structure showed a slight increase. After filling the MTA on the 6th day of examination, the immediate inflammatory response was insignificant. Neutrophils were observed to enter the region surrounding the retrofilled MTA, and a small number of osteoclasts were observed to be resorbing bone. Around the wound site, fibroblasts can also be detected. On the 16th day, unlike ZOE, a lot of new bone grows close to this material.

Conclusion: MTA has the ability to modulate periapical healing in rat molar.

Citing Articles

Comparative analysis of viability, proliferation, and mineralization potential of human pulp and osteoblastic cells exposed to different bioceramic endodontic sealers.

Santiago M, Henrique de Oliveira Salles G, Gomes de Lima G, Alves de Oliveira L, Salles L J Oral Biol Craniofac Res. 2025; 15(1):191-198.

PMID: 39897436 PMC: 11782589. DOI: 10.1016/j.jobcr.2025.01.008.

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