Neuroendocrine Effects of the Duper Mutation in Syrian Hamsters: a Role for

Overview

Journal Front Physiol

Date 2024 Mar 6

PMID 38444761

Authors

Emily N C Manoogian

Michael Seifu Bahiru

Emily Jue Wang

Mary Holder

Eric L Bittman

Affiliations

Soon will be listed here.

Abstract

Molecular and physiological determinants of the timing of reproductive events, including the pre-ovulatory LH surge and seasonal fluctuations in fertility, are incompletely understood. We used the -deficient duper mutant to examine the role of this core circadian clock gene in Syrian hamsters. We find that the phase of the LH surge and its stability upon shifts of the light: dark cycle are altered in duper mutants. The intensity of immunoreactive PER1 in GnRH cells of the preoptic area peaks earlier in the day in duper than wild type hamsters. We note that GnRH fibers coursing through the suprachiasmatic nucleus (SCN) contact vasopressin- and VIP-immunoreactive cells, suggesting a possible locus of circadian control of the LH surge. Unlike wild types, duper hamsters do not regress their gonads within 8 weeks of constant darkness, despite evidence of melatonin secretion during the subjective night. In light of the finding that the duper allele is a stop codon in , our results suggest important neuroendocrine functions of this core circadian clock gene.

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