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Taking It Back to Basics: Re-emphasizing the Role of Moisturization in Atopic Dermatitis

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Date 2024 Mar 6
PMID 38444427
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Abstract

Atopic dermatitis (AD) is a common, burdensome inflammatory skin disease. In recent years, multiple safe and effective monotherapy treatments directly targeting immune dysregulation in AD have been approved and integrated into clinical practice. Although the etiopathogenesis of AD is complex, it is widely recognized that alongside immune dysregulation, skin barrier disruption also plays an essential role in disease pathophysiology. For this reason, regular moisturization has been a foundational mainstay of therapy, consistently recommended by treatment guidelines regardless of disease severity or therapeutic approach. It is vital for healthcare providers to continuously educate patients and caregivers about the importance of optimizing skin barrier function by maintaining proper moisturization as part of their treatment plan and help them make data-driven decisions to navigate the wide array of available products.

References
1.
Kemeny L, Varga E, Novak Z . Advances in phototherapy for psoriasis and atopic dermatitis. Expert Rev Clin Immunol. 2019; 15(11):1205-1214. DOI: 10.1080/1744666X.2020.1672537. View

2.
Margolis D, Mitra N, Gochnauer H, Wubbenhorst B, DAndrea K, Kraya A . Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans. J Invest Dermatol. 2018; 138(7):1501-1506. PMC: 6272058. DOI: 10.1016/j.jid.2018.01.029. View

3.
Niedzwiedz M, Skibinska M, Narbutt J, Lesiak A . Off-label medications in the treatment of hospitalized children with atopic dermatitis. Postepy Dermatol Alergol. 2023; 40(1):72-77. PMC: 9993195. DOI: 10.5114/ada.2022.119967. View

4.
Flohr C . How we treat atopic dermatitis now and how that will change over the next 5 years. Br J Dermatol. 2023; 188(6):718-725. DOI: 10.1093/bjd/ljac116. View

5.
Paller A, Siegfried E, Thaci D, Wollenberg A, Cork M, Arkwright P . Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: A randomized, double-blinded, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2020; 83(5):1282-1293. DOI: 10.1016/j.jaad.2020.06.054. View