Non-cytopathic Bovine Viral Diarrhea Virus (BVDV) Inhibits Innate Immune Responses Via Induction of Mitophagy

Overview

Journal Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2024 Mar 5

PMID 38443986

Authors

Zhijun Li

Ying Zhang

Bao Zhao

Qinghong Xue

Chunjiang Wang

Siyu Wan

Jingyu Wang

Xiwen Chen

Xuefeng Qi

Affiliations

Soon will be listed here.

Abstract

Bovine viral diarrhea virus (BVDV) belongs to the genus Pestivirus within the family Flaviviridae. Mitophagy plays important roles in virus-host interactions. Here, we provide evidence that non-cytopathic (NCP) BVDV shifts the balance of mitochondrial dynamics toward fission and induces mitophagy to inhibit innate immune responses. Mechanistically, NCP BVDV triggers the translocation of dynamin-related protein (Drp1) to mitochondria and stimulates its phosphorylation at Ser616, leading to mitochondrial fission. In parallel, NCP BVDV-induced complete mitophagy via Parkin-dependent pathway contributes to eliminating damaged mitochondria to inhibit MAVS- and mtDNA-cGAS-mediated innate immunity responses, mtROS-mediated inflammatory responses and apoptosis initiation. Importantly, we demonstrate that the LIR motif of E is essential for mitophagy induction. In conclusion, this study is the first to show that NCP BVDV-induced mitophagy plays a central role in promoting cell survival and inhibiting innate immune responses in vitro.

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