A Comprehensive Evaluation of Risk Factors for Mortality, Infection and Colonization Associated with CRGNB in Adult Solid Organ Transplant Recipients: a Systematic Review and Meta-analysis

Overview

Journal Ann Med

Publisher Informa Healthcare

Specialty General Medicine

Date 2024 Mar 5

PMID 38442299

Authors

Siyu Gao

Xiaoli Huang

Xiaolin Zhou

Xiangcheng Dai

Jing Han

Yandong Chen

Hongliang Qiao

Yi Li

Yifan Zhou

Ting Wang

Huiqing He

Qiang Liu

Shenjie Tang

Affiliations

Soon will be listed here.

Abstract

Background: The burden of carbapenem-resistant gram-negative bacteria (CRGNB) among solid organ transplant (SOT) recipients has not been systematically explored. Here, we discern the risk factors associated with CRGNB infection and colonization in SOT recipients.

Methods: This study included observational studies conducted among CRGNB-infected SOT patients, which reported risk factors associated with mortality, infection or colonization. Relevant records will be searched in PubMed, Embase and Web of Science for the period from the time of database construction to 1 March 2023.

Results: A total of 23 studies with 13,511 participants were included, enabling the assessment of 27 potential risk factors. The pooled prevalence of 1-year mortality among SOT recipients with CRGNB was 44.5%. Prolonged mechanical ventilation, combined transplantation, reoperation and pre-transplantation CRGNB colonization are salient contributors to the occurrence of CRGNB infections in SOT recipients. Renal replacement therapy, post-LT CRGNB colonization, pre-LT liver disease and model for end-stage liver disease score increased the risk of infection. Re-transplantation, carbapenem use before transplantation and ureteral stent utilization increaesd risk of CRGNB colonization.

Conclusion: Our study demonstrated that SOT recipients with CRGNB infections had a higher mortality risk. Invasive procedure may be the main factor contribute to CRGNB infection.

Citing Articles

Incidence, risk factors and clinical outcome of multidrug-resistant organisms after heart transplantation.

Hatzianastasiou S, Vlachos P, Stravopodis G, Elaiopoulos D, Koukousli A, Papaparaskevas J World J Transplant. 2024; 14(2):93567.

PMID: 38947964 PMC: 11212582. DOI: 10.5500/wjt.v14.i2.93567.

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