Association Between Sedentary Behavior and Brain-Derived Neurotrophic Factor (BDNF) in Children and Adolescents: A Protocol for Systematic Review and Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Mar 5

PMID 38442097

Authors

Victor Hugo de Oliveira Segundo

Kesley Pablo Morais de Azevedo

Gidyenne Christine Bandeira Silva de Medeiros

Adala Nayana de Sousa Mata

Grasiela Piuvezam

Affiliations

Soon will be listed here.

Abstract

Background: There is evidence in the literature suggesting that high time spent in sedentary behavior (SB) can reduce the Brain-Derived Neurotrophic Factor (BDNF) levels, an important neurotrophin that plays a role in modulating cognition, learning and memory. Children and adolescents usually spend many hours a day on SB, either sitting for a long time and/or using screen equipment.

Objective: The aim of this study is to describe a systematic review and meta-analysis protocol on the associations between SB and BDNF levels in children and adolescents.

Methods: This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols and was published in the International Prospective Register of Systematic Reviews database (PROSPERO: CRD42023392246). The databases that will be searched are EMBASE, Scopus, ScienceDirect, Web of Science, SPORTDiscus, CINAHL, and PubMed. Cross-sectional and cohort studies conducted with children and adolescents (5 to 19 yr) that analyzed the association between SB and BDNF will be included in the systematic review. The characteristics of the studies, methodological aspects, and main results will be described. Then, the risk of bias (assessed by STROBE and Newcastle-Ottawa scales) and the level of evidence (assessed by the GRADE tool) from included studies will be evaluated. Sub-group analysis will also be performed. Two experienced reviewers will perform the studies selection, data extraction, and methodological quality assessment.

Conclusion: This systematic review and meta-analysis will analyze the association between SB and BDNF in children and adolescents. The results will provide subsidies to better understand this relationship and will strengthen evidence-based practice for both health professionals and future researches.

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References

Gabel L, Ridgers N, Della Gatta P, Arundell L, Cerin E, Robinson S . Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in children. Pediatr Obes. 2015; 11(3):194-201. PMC: 5054926. DOI: 10.1111/ijpo.12045. View

Huang T, Gejl A, Tarp J, Andersen L, Peijs L, Bugge A . Cross-sectional associations of objectively measured physical activity with brain-derived neurotrophic factor in adolescents. Physiol Behav. 2016; 171:87-91. DOI: 10.1016/j.physbeh.2016.12.026. View

Mugler N, Baurecht H, Lam K, Leitzmann M, Jochem C . The Effectiveness of Interventions to Reduce Sedentary Time in Different Target Groups and Settings in Germany: Systematic Review, Meta-Analysis and Recommendations on Interventions. Int J Environ Res Public Health. 2022; 19(16). PMC: 9408392. DOI: 10.3390/ijerph191610178. View

Tremblay M, Aubert S, Barnes J, Saunders T, Carson V, Latimer-Cheung A . Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act. 2017; 14(1):75. PMC: 5466781. DOI: 10.1186/s12966-017-0525-8. View

Rodriguez-Gutierrez E, Torres-Costoso A, Saz-Lara A, Bizzozero-Peroni B, Guzman-Pavon M, Sanchez-Lopez M . Effectiveness of high-intensity interval training on peripheral brain-derived neurotrophic factor in adults: A systematic review and network meta-analysis. Scand J Med Sci Sports. 2023; 34(1):e14496. DOI: 10.1111/sms.14496. View

von Elm E, Altman D, Egger M, Pocock S, Gotzsche P, Vandenbroucke J . The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007; 147(8):573-7. DOI: 10.7326/0003-4819-147-8-200710160-00010. View

Carson V, Hunter S, Kuzik N, Gray C, Poitras V, Chaput J . Systematic review of sedentary behaviour and health indicators in school-aged children and youth: an update. Appl Physiol Nutr Metab. 2016; 41(6 Suppl 3):S240-65. DOI: 10.1139/apnm-2015-0630. View

Mora-Gonzalez J, Migueles J, Esteban-Cornejo I, Cadenas-Sanchez C, Pastor-Villaescusa B, Molina-Garcia P . Sedentarism, Physical Activity, Steps, and Neurotrophic Factors in Obese Children. Med Sci Sports Exerc. 2019; 51(11):2325-2333. DOI: 10.1249/MSS.0000000000002064. View

Jose de Menezes-Junior F, Jesus I, Brand C, Mota J, Leite N . Physical Exercise and Brain-Derived Neurotrophic Factor Concentration in Children and Adolescents: A Systematic Review With Meta-Analysis. Pediatr Exerc Sci. 2021; 34(1):44-53. DOI: 10.1123/pes.2020-0207. View

10.

Goldfield G, Cameron J, Sigal R, Kenny G, Holcik M, Prudhomme D . Screen time is independently associated with serum brain-derived neurotrophic factor (BDNF) in youth with obesity. Appl Physiol Nutr Metab. 2021; 46(9):1083-1090. DOI: 10.1139/apnm-2020-0756. View

11.

Li S, Guo J, Zheng K, Shi M, Huang T . Is Sedentary Behavior Associated With Executive Function in Children and Adolescents? A Systematic Review. Front Public Health. 2022; 10:832845. PMC: 8847290. DOI: 10.3389/fpubh.2022.832845. View

12.

Dahl R, Allen N, Wilbrecht L, Suleiman A . Importance of investing in adolescence from a developmental science perspective. Nature. 2018; 554(7693):441-450. DOI: 10.1038/nature25770. View

13.

Gomes M, Tractenberg S, Orso R, Viola T, Grassi-Oliveira R . Sex differences in risk behavior parameters in adolescent mice: Relationship with brain-derived neurotrophic factor in the medial prefrontal cortex. Neurosci Lett. 2021; 766:136339. DOI: 10.1016/j.neulet.2021.136339. View

14.

Blakemore S, Mills K . Is adolescence a sensitive period for sociocultural processing?. Annu Rev Psychol. 2013; 65:187-207. DOI: 10.1146/annurev-psych-010213-115202. View

15.

Li Y, Li F, Qin D, Chen H, Wang J, Wang J . The role of brain derived neurotrophic factor in central nervous system. Front Aging Neurosci. 2022; 14:986443. PMC: 9493475. DOI: 10.3389/fnagi.2022.986443. View

16.

Somerville L, Jones R, Casey B . A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain Cogn. 2009; 72(1):124-33. PMC: 2814936. DOI: 10.1016/j.bandc.2009.07.003. View

17.

Marosi K, Mattson M . BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2013; 25(2):89-98. PMC: 3915771. DOI: 10.1016/j.tem.2013.10.006. View

18.

Hecht E, Williams A, Abrams G, Passman R . Cardiovascular Risk Factors in Young Adolescents: Results from the National Health and Nutrition Examination Survey 1988-2016. South Med J. 2021; 114(5):261-265. DOI: 10.14423/SMJ.0000000000001244. View

19.

Loprinzi P . The effects of sedentary behavior on memory and markers of memory function: a systematic review. Phys Sportsmed. 2019; 47(4):387-394. DOI: 10.1080/00913847.2019.1607603. View

20.

Mattila V, Parkkari J, Koivusilta L, Nummi T, Kannus P, Rimpela A . Adolescents' health and health behaviour as predictors of injury death. A prospective cohort follow-up of 652,530 person-years. BMC Public Health. 2008; 8:90. PMC: 2292710. DOI: 10.1186/1471-2458-8-90. View