Regional Lymph Node Evaluation in Pediatric Conventional Melanoma Subtype: a Single-center 10-year Review

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2024 Mar 5

PMID 38441654

Authors

Pattamon Sutthatarn

Andrew M Davidoff

Armita Bahrami

Celine Richard

Bhatia Shalini

Teresa C Santiago

Barry L Shulkin

Alberto S Pappo

Abdelhafeez Abdelhafeez

Affiliations

Soon will be listed here.

Abstract

Purpose: To assess the prognostic and therapeutic significance of sentinel lymph node biopsy (SLNB) and completion lymph node dissection (CLND) in pediatric conventional melanoma (CM), while evaluating potential predictive factors for outcomes.

Methods: We conducted a retrospective analysis of medical records spanning 2009-2020, focusing on patients aged 18 or younger with localized cutaneous conventional melanoma.

Results: Among the 33 patients, SLNB detected metastasis in 57.6% of cases, with 52.6% undergoing CLND. Positive SLN patients had higher relapse risk (HR 5.92; 95% CI 1.27-27.7; P = 0.024) but similar overall survival (HR 3.19; 95% CI 0.31-33.1, P = 0.33). No significant differences in disease-free survival (DFS) and OS were found between patients who underwent CLND and those who did not (HR 1.91; 95% CI 0.49-7.43, P = 0.35, and HR 0.52; 95% CI 0.03-8.32, P = 0.64, respectively). Univariate analysis showed age at diagnosis (P = 0.02) correlated with higher recurrence risk, with a 21% hazard increase per additional year of age.

Conclusions: Positive SLN status and age at diagnosis were associated with worse DFS in CM patients. Our study did not find any prognostic or therapeutic value in CLND for pediatric melanoma. Further multicenter trials are needed to confirm our single-institution experience.

Level Of Evidence: Level IV.

Citing Articles

Nevi and Melanoma in Children: What to Do in Daily Medical Practice: Encyclopedia for Pediatricians and Family Doctors.

Sosnowska-Sienkiewicz P, Januszkiewicz-Lewandowska D, Calik J, Telman-Kolodziejczyk G, Mankowski P Diagnostics (Basel). 2024; 14(18).

PMID: 39335684 PMC: 11431136. DOI: 10.3390/diagnostics14182004.

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