Stat3 Activation-triggered Transcriptional Networks Govern the Early Stage of HBV-induced Hepatic Inflammation

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Mar 5

PMID 38440978

Authors

Jinglin Tang

Jiaxuan Zhang

Gaoli Zhang

Wenhui Peng

Ning Ling

Yingzhi Zhou

Hongmei Xu

Hong Ren

Min Chen

Affiliations

Soon will be listed here.

Abstract

Importance: Until now, it remains a mystery that chronic hepatitis B virus (HBV)-infected patients in the "immune tolerance phase" will transition to the "immune activation phase" as they age. In this study, we reveal that Stat3 activation-triggered hepatic transcriptional alterations are distinctive characteristics of the early stage of immune/inflammation activation in chronic HBV infection. For the first time, we discover a mechanism that might trigger the transition from immune tolerance to immune activation in chronic HBV carriers.

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