Biogenesis, Germination, and Pathogenesis of Spores

Overview

Journal Microbiol Mol Biol Rev

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Mar 5

PMID 38440970

Authors

Sebastien C Ortiz

Christina M Hull

Affiliations

Soon will be listed here.

Abstract

SUMMARYSpores are primary infectious propagules for the majority of human fungal pathogens; however, relatively little is known about their fundamental biology. One strategy to address this deficiency has been to develop the basidiospores of into a model for pathogenic spore biology. Here, we provide an update on the state of the field with a comprehensive review of the data generated from the study of basidiospores from their formation (sporulation) and differentiation (germination) to their roles in pathogenesis. Importantly, we provide support for the presence of basidiospores in nature, define the key characteristics that distinguish basidiospores from yeast cells, and clarify their likely roles as infectious particles. This review is intended to demonstrate the importance of basidiospores in the field of research and provide a solid foundation from which researchers who wish to study sexual spores in any fungal system can launch their studies.

Citing Articles

Tracing the evolution and genomic dynamics of mating-type loci in pathogens and closely related species.

Coelho M, David-Palma M, Marincowitz S, Aylward J, Pham N, Yurkov A bioRxiv. 2025; .

PMID: 39990455 PMC: 11844451. DOI: 10.1101/2025.02.12.637874.

References

van Leeuwen M, Krijgsheld P, Bleichrodt R, Menke H, Stam H, Stark J . Germination of conidia of Aspergillus niger is accompanied by major changes in RNA profiles. Stud Mycol. 2013; 74(1):59-70. PMC: 3563291. DOI: 10.3114/sim0009. View

Kwon-Chung K . A new genus, filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia. 1975; 67(6):1197-200. View

Skosireva I, James T, Sun S, Xu J . Mitochondrial inheritance in haploid x non-haploid crosses in Cryptococcus neoformans. Curr Genet. 2010; 56(2):163-76. DOI: 10.1007/s00294-010-0289-z. View

Sun S, Fu C, Ianiri G, Heitman J . The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance in . Genetics. 2020; 214(3):703-717. PMC: 7054021. DOI: 10.1534/genetics.119.302824. View

Fleming S, Yannakou C, Haeusler G, Clark J, Grigg A, Heath C . Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014. Intern Med J. 2014; 44(12b):1283-97. DOI: 10.1111/imj.12595. View

Kwon-Chung K . Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia. 1976; 68(4):821-33. View

Mao B, Tang H, Gu J, Li D, Cui S, Zhao J . In vitro fermentation of raffinose by the human gut bacteria. Food Funct. 2018; 9(11):5824-5831. DOI: 10.1039/c8fo01687a. View

Lamarre C, Sokol S, Debeaupuis J, Henry C, Lacroix C, Glaser P . Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus conidia. BMC Genomics. 2008; 9:417. PMC: 2556354. DOI: 10.1186/1471-2164-9-417. View

Yan Z, Sun S, Shahid M, Xu J . Environment factors can influence mitochondrial inheritance in the fungus Cryptococcus neoformans. Fungal Genet Biol. 2006; 44(5):315-22. DOI: 10.1016/j.fgb.2006.10.002. View

10.

Bulmer G . Twenty-five years with Cryptococcus neoformans. Mycopathologia. 1990; 109(2):111-22. DOI: 10.1007/BF00436791. View

11.

Saul N, Krockenberger M, Carter D . Evidence of recombination in mixed-mating-type and alpha-only populations of Cryptococcus gattii sourced from single eucalyptus tree hollows. Eukaryot Cell. 2008; 7(4):727-34. PMC: 2292630. DOI: 10.1128/EC.00020-08. View

12.

Kline M, Jacobson E . Auxotrophic markers and the cytogenetics of Filobasidiella neoformans. Mycopathologia. 1981; 76(2):115-7. DOI: 10.1007/BF00443758. View

13.

Villalobos A, Husain S . Infection prophylaxis and management of fungal infections in lung transplant. Ann Transl Med. 2020; 8(6):414. PMC: 7186682. DOI: 10.21037/atm.2020.03.102. View

14.

Fraser J, Giles S, Wenink E, Geunes-Boyer S, Wright J, Diezmann S . Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature. 2005; 437(7063):1360-4. DOI: 10.1038/nature04220. View

15.

Nishimura Y, Shikanai T, Kawamoto S, Toh-E A . Step-wise elimination of α-mitochondrial nucleoids and mitochondrial structure as a basis for the strict uniparental inheritance in Cryptococcus neoformans. Sci Rep. 2020; 10(1):2468. PMC: 7016115. DOI: 10.1038/s41598-020-59277-9. View

16.

Ortiz S, Huang M, Hull C . Spore Germination as a Target for Antifungal Therapeutics. Antimicrob Agents Chemother. 2019; 63(12). PMC: 6879269. DOI: 10.1128/AAC.00994-19. View

17.

NEILSON J, Fromtling R, Bulmer G . Cryptococcus neoformans: size range of infectious particles from aerosolized soil. Infect Immun. 1977; 17(3):634-8. PMC: 421174. DOI: 10.1128/iai.17.3.634-638.1977. View

18.

Yan Z, Hull C, Sun S, Heitman J, Xu J . The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Curr Genet. 2006; 51(3):187-95. DOI: 10.1007/s00294-006-0115-9. View

19.

Lin X, Patel S, Litvintseva A, Floyd A, Mitchell T, Heitman J . Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. PLoS Pathog. 2009; 5(1):e1000283. PMC: 2629120. DOI: 10.1371/journal.ppat.1000283. View

20.

Yan Z, Hull C, Heitman J, Sun S, Xu J . SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans. Curr Biol. 2004; 14(18):R743-4. DOI: 10.1016/j.cub.2004.09.008. View