[Value of the Human Chorionic Gonadotropin Stimulation Test in the Diagnosis of Disorder of Sexual Development in Children]

Overview

Journal Zhongguo Dang Dai Er Ke Za Zhi

Specialty Pediatrics

Date 2024 Mar 4

PMID 38436313

Authors

Cui-Li Liang

Guo-Chang Liu

Jing Cheng

Hui-Lin Niu

Wen Fu

Li-Yu Zhang

Wei Jia

Wen Zhang

Li Liu

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate the value of the human chorionic gonadotropin (hCG) stimulation test in the diagnosis of disorder of sexual development (DSD) in children.

Methods: A retrospective analysis was conducted on 132 children with DSD. According to the karyotype, they were divided into three groups: 46,XX group (=10), 46,XY group (=87), and sex chromosome abnormality group (=35). The above groups were compared in terms of sex hormone levels before and after hCG stimulation test, and the morphological manifestation of the impact of testicular tissue on the results of the hCG stimulation test was analyzed.

Results: There was no significant difference in the multiple increase of testosterone after stimulation among the three groups (0.05). In the 46,XY group, the children with 5α-reductase type 2 deficiency had a testosterone-to-dihydrotestosterone ratio higher than that of the 46,XY DSD children with other causes. Morphological analysis showed that DSD children with testicular tissue demonstrated a significantly higher multiple increase in testosterone after stimulation compared to children without testicular tissue (<0.05).

Conclusions: The hCG stimulation test has an important value in assessing the presence and function of testicular interstitial cells in children with different types of DSD, and it is recommended to perform the hCG stimulation test for DSD children with unclear gonadal type.

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