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Unveiling a Rare Side Effect: A Report of a Unique Case of Second-Degree Type 2 Sinoatrial Node Exit Block Induced by Adenosine Infusion

Overview
Journal Cureus
Date 2024 Mar 4
PMID 38435879
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Abstract

Adenosine is a widely used pharmacologic agent in the field of cardiology, predominantly for the termination of supraventricular tachycardias and diagnostic purposes. Most of the side effects are short-lasting due to its very short half-life. Fatal complications of adenosine are rare but can include ventricular fibrillation, ventricular tachycardia, and asystole. Proper medical supervision and monitoring are crucial to minimize risks. We report a unique case of a second-degree type 2 sinoatrial node exit block following intravenous adenosine administration in a 25-year-old male presenting with palpitations.

References
1.
Mustafa S, Morrison R, Teng B, Pelleg A . Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol. 2009; (193):161-88. PMC: 2913612. DOI: 10.1007/978-3-540-89615-9_6. View

2.
Tan H, Spekhorst H, Peters R, Wilde A . Adenosine induced ventricular arrhythmias in the emergency room. Pacing Clin Electrophysiol. 2001; 24(4 Pt 1):450-5. DOI: 10.1046/j.1460-9592.2001.00450.x. View

3.
Guieu R, Deharo J, Maille B, Crotti L, Torresani E, Brignole M . Adenosine and the Cardiovascular System: The Good and the Bad. J Clin Med. 2020; 9(5). PMC: 7290927. DOI: 10.3390/jcm9051366. View

4.
Wesley Jr R, Turnquest P . Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome. Am Heart J. 1992; 123(3):794-6. DOI: 10.1016/0002-8703(92)90525-z. View

5.
Williams M . Purine receptors in mammalian tissues: pharmacology and functional significance. Annu Rev Pharmacol Toxicol. 1987; 27:315-45. DOI: 10.1146/annurev.pa.27.040187.001531. View