Bidirectional Mechanism of Comorbidity of Depression and Insomnia Based on Synaptic Plasticity

Overview

Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2024 Mar 3

PMID 38432881

Authors

Fanhao Meng

Long Wang

Affiliations

Soon will be listed here.

Abstract

Insomnia is one of the most common accompanying symptoms of depression, with both sharing highly overlapping molecular pathways. The same pathological changes can trigger comorbidity of insomnia and depression, which further forms a vicious cycle with the involvement of more mechanisms and disease progression. Thus, understanding the potential interaction mechanisms between insomnia and depression is critical for clinical diagnosis and treatment. Comorbidity genetic factors, the hypothalamic-pituitary-adrenal axis, along with circadian rhythms of cortisol and the brain reward mechanism, are important ways in contributing to the comorbidity occurrence and development. However, owing to lack of pertinent investigational data, intricate molecular mechanisms necessitate further elaboration. Synaptic plasticity is a solid foundation for neural homeostasis. Pathological alterations of depression and insomnia may perturb the production and release of neurotransmitter, dendritic spine remodeling and elimination, which converges and reflects in aberrant synaptic dynamics. Hence, the introduction of synaptic plasticity research route and the construction of a comprehensive model of depression and insomnia comorbidity can provide new ideas for clinical depression insomnia comorbidity treatment plans.

References

Speranza L, di Porzio U, Viggiano D, de Donato A, Volpicelli F . Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control. Cells. 2021; 10(4). PMC: 8066851. DOI: 10.3390/cells10040735. View

Everitt H, Baldwin D, Stuart B, Lipinska G, Mayers A, Malizia A . Antidepressants for insomnia in adults. Cochrane Database Syst Rev. 2018; 5:CD010753. PMC: 6494576. DOI: 10.1002/14651858.CD010753.pub2. View

Lenz M, Eichler A, Vlachos A . Monitoring and Modulating Inflammation-Associated Alterations in Synaptic Plasticity: Role of Brain Stimulation and the Blood-Brain Interface. Biomolecules. 2021; 11(3). PMC: 7996828. DOI: 10.3390/biom11030359. View

Lin Y, Wang C, Chen C . GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways between Major Depressive Disorder and Insomnia. Genes (Basel). 2021; 12(10). PMC: 8536096. DOI: 10.3390/genes12101506. View

Worthen R, Garzon Zighelboim S, Torres Jaramillo C, Beurel E . Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice. J Neuroinflammation. 2020; 17(1):246. PMC: 7443292. DOI: 10.1186/s12974-020-01922-1. View

Law R, Clow A . Stress, the cortisol awakening response and cognitive function. Int Rev Neurobiol. 2020; 150:187-217. DOI: 10.1016/bs.irn.2020.01.001. View

Gujar N, Yoo S, Hu P, Walker M . Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences. J Neurosci. 2011; 31(12):4466-74. PMC: 3086142. DOI: 10.1523/JNEUROSCI.3220-10.2011. View

Anacker C, Cattaneo A, Musaelyan K, Zunszain P, Horowitz M, Molteni R . Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2013; 110(21):8708-13. PMC: 3666742. DOI: 10.1073/pnas.1300886110. View

Zhao Y, Jin Y, Rao W, Zhang Q, Zhang L, Jackson T . Prevalence of Major Depressive Disorder Among Adults in China: A Systematic Review and Meta-Analysis. Front Psychiatry. 2021; 12:659470. PMC: 8219051. DOI: 10.3389/fpsyt.2021.659470. View

10.

Katoh-Semba R, Tsuzuki M, Miyazaki N, Matsuda M, Nakagawa C, Ichisaka S . A phase advance of the light-dark cycle stimulates production of BDNF, but not of other neurotrophins, in the adult rat cerebral cortex: association with the activation of CREB. J Neurochem. 2008; 106(5):2131-42. DOI: 10.1111/j.1471-4159.2008.05565.x. View

11.

Tancredi S, Urbano T, Vinceti M, Filippini T . Artificial light at night and risk of mental disorders: A systematic review. Sci Total Environ. 2022; 833:155185. DOI: 10.1016/j.scitotenv.2022.155185. View

12.

Linkowski P . Neuroendocrine profiles in mood disorders. Int J Neuropsychopharmacol. 2003; 6(2):191-7. DOI: 10.1017/S1461145703003407. View

13.

Licznerski P, Duric V, Banasr M, Alavian K, Ota K, Kang H . Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLoS Biol. 2015; 13(10):e1002282. PMC: 4623974. DOI: 10.1371/journal.pbio.1002282. View

14.

Madore C, Yin Z, Leibowitz J, Butovsky O . Microglia, Lifestyle Stress, and Neurodegeneration. Immunity. 2020; 52(2):222-240. PMC: 7234821. DOI: 10.1016/j.immuni.2019.12.003. View

15.

Gourley S, Wu F, Kiraly D, Ploski J, Kedves A, Duman R . Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Biol Psychiatry. 2007; 63(4):353-9. PMC: 2277331. DOI: 10.1016/j.biopsych.2007.07.016. View

16.

Massar S, Liu J, Mohammad N, Chee M . Poor habitual sleep efficiency is associated with increased cardiovascular and cortisol stress reactivity in men. Psychoneuroendocrinology. 2017; 81:151-156. DOI: 10.1016/j.psyneuen.2017.04.013. View

17.

Xia L, Zhang P, Niu J, Ge W, Chen J, Yang S . Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study. Nat Sci Sleep. 2021; 13:1419-1428. PMC: 8369225. DOI: 10.2147/NSS.S310698. View

18.

Beurel E, Toups M, Nemeroff C . The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron. 2020; 107(2):234-256. PMC: 7381373. DOI: 10.1016/j.neuron.2020.06.002. View

19.

Cai M, Park H, Yang E . Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic-Pituitary-Adrenal Axis. Pharmaceuticals (Basel). 2022; 15(7). PMC: 9324528. DOI: 10.3390/ph15070898. View

20.

Katz G, Knobler H, Laibel Z, Strauss Z, Durst R . Time zone change and major psychiatric morbidity: the results of a 6-year study in Jerusalem. Compr Psychiatry. 2002; 43(1):37-40. DOI: 10.1053/comp.2002.29849. View