Feasibility Pilot Trial of a Tailored Medication Adherence-promotion Intervention for Adolescents and Young Adults with Cancer: Study Design and Protocol

Overview

Journal Contemp Clin Trials

Publisher Elsevier

Date 2024 Mar 2

PMID 38431133

Authors

Meghan E McGrady

Tyler G Ketterl

Rachel Tillery Webster

Laura E Schwartz

Margaret Y Brock

Lauren Szulczewski

Macks Burke

Kevin A Hommel

Ahna L H Pai

Constance A Mara

Amii C Steele

Gillian G Regan

Robin E Norris

Affiliations

Soon will be listed here.

Abstract

Background: Medication non-adherence is common among adolescents and young adults (AYAs) with cancer and associated with poor health outcomes. AYAs with cancer endorse multiple barriers to adherence that differ across individuals, suggesting that tailoring intervention content to an AYA's specific barriers may have the potential to improve adherence. The purpose of this manuscript is to report on ORBIT-guided Phase I design efforts to create the first tailored adherence-promotion intervention for AYAs with cancer and the study protocol for the ongoing Phase II pilot feasibility trial.

Methods: Phase I design included qualitative interviews (n = 15 AYAs) to understand patient preferences for adherence-promotion care, development and refinement of a best-worst scaling exercise barriers tool (n = 5 AYAs), and development of intervention modules and a tailoring algorithm. In the ongoing Phase II pilot feasibility trial, AYAs (ages 15-24 years) with cancer currently taking oral chemotherapy or prophylactic medication will be recruited from three children's hospitals. Feasibility, acceptability, and usability will be assessed and these outcomes along with data on medication adherence will be used to inform the next phases of intervention development and testing.

Conclusions: If promising, this program of research ultimately has the potential to equip clinicians with additional strategies for supporting adherence among AYAs with cancer. NCT05706610.

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