Promoting Collateral Formation in Type 2 Diabetes Mellitus Using Ultra-small Nanodots with Autophagy Activation and ROS Scavenging

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2024 Mar 1

PMID 38429826

Authors

Yixuan Wang

Feifei Li

Linshuang Mao

Yu Liu

Shuai Chen

Jingmeng Liu

Ke Huang

Qiujing Chen

Jianrong Wu

Lin Lu

Yuanyi Zheng

Weifeng Shen

Tao Ying

Yang Dai

Ying Shen

Affiliations

Soon will be listed here.

Abstract

Background: Impaired collateral formation is a major factor contributing to poor prognosis in type 2 diabetes mellitus (T2DM) patients with atherosclerotic cardiovascular disease. However, the current pharmacological treatments for improving collateral formation remain unsatisfactory. The induction of endothelial autophagy and the elimination of reactive oxygen species (ROS) represent potential therapeutic targets for enhancing endothelial angiogenesis and facilitating collateral formation. This study investigates the potential of molybdenum disulfide nanodots (MoS NDs) for enhancing collateral formation and improving prognosis.

Results: Our study shows that MoS NDs significantly enhance collateral formation in ischemic tissues of diabetic mice, improving effective blood resupply. Additionally, MoS NDs boost the proliferation, migration, and tube formation of endothelial cells under high glucose/hypoxia conditions in vitro. Mechanistically, the beneficial effects of MoS NDs on collateral formation not only depend on their known scavenging properties of ROS (HO, •O, and •OH) but also primarily involve a molecular pathway, cAMP/PKA-NR4A2, which promotes autophagy and contributes to mitigating damage in diabetic endothelial cells.

Conclusions: Overall, this study investigated the specific mechanism by which MoS NDs mediated autophagy activation and highlighted the synergy between autophagy activation and antioxidation, thus suggesting that an economic and biocompatible nano-agent with dual therapeutic functions is highly preferable for promoting collateral formation in a diabetic context, thus, highlighting their therapeutic potential.

Citing Articles

Elevated systemic immune-inflammatory index predicts poor coronary collateralization in type 2 diabetic patients with chronic total occlusion.

Mao L, Wang Y, Wu Z, Ding F, Lu L, Shen W Front Cardiovasc Med. 2024; 11:1490498.

PMID: 39735863 PMC: 11672344. DOI: 10.3389/fcvm.2024.1490498.

Advances in Theranostic Approaches and Emerging Biomarkers of Diabetes Mellitus.

Aktas G Diagnostics (Basel). 2024; 14(19).

PMID: 39410611 PMC: 11475579. DOI: 10.3390/diagnostics14192207.

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