Noninvasive Neuromodulation Protects Against Doxorubicin-induced Cardiotoxicity and Inhibits Tumor Growth

Overview

Journal iScience

Publisher Cell Press

Date 2024 Mar 1

PMID 38425841

Authors

Mengjie Xie

Fuding Guo

Lingpeng Song

Wuping Tan

Xinrui Han

Saiting Xu

Xujun Li

Yijun Wang

Yueyi Wang

Liping Zhou

Xiaoya Zhou

Hong Jiang

Lilei Yu

Affiliations

Soon will be listed here.

Abstract

Doxorubicin (Dox) poses a considerable threat to patients owing to its cardiotoxicity, thus limiting its clinical utility. Optimal cardioprotective intervention strategies are needed to suppress tumor growth but also minimize cardiac side effects. Here, we showed that tragus vagus nerve stimulation (tVNS) improved the imbalanced autonomic tone, ameliorated impaired cardiac function and fibrosis, attenuated myocyte apoptosis, and mitochondrial dysfunction compared to those in the Dox group. The beneficial effects were attenuated by methyllycaconitine citrate (MLA). The transcript profile revealed that there were 312 differentially expressed genes and the protection of tVNS and retardation of MLA were related to inflammatory response and NADPH oxidase activity. In addition, tVNS synergizing with Dox inhibited tumor growth and lung metastasis and promoted apoptosis of tumor cells in an anti-tumor immunity manner. These results indicated that non-invasive neuromodulation can play a dual role in preventing Dox-induced cardiotoxicity and suppressing tumor growth through inflammation and oxidative stress.

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