Antibiotic Disposal Challenges in India: Investigating Causes and Effects

Overview

Journal Environ Monit Assess

Publisher Springer

Specialty Environmental Health

Date 2024 Feb 29

PMID 38421517

Authors

Samradhi Singh

Poonam Sharma

Namrata Pal

Devojit Kumar Sarma

Manoj Kumar

Affiliations

Soon will be listed here.

Abstract

Antibiotic resistance has become a global problem and India emerges as a key battlefield in the fight against it. While inappropriate use of antibiotics is well known, the review article deliberates a less recognized yet equally perilous facet of the crisis i.e. improper antibiotic disposal. An investigation of the sources of antibiotic pollution in Indian water bodies identifies discharge of pharmaceutical effluents, hospital waste, and agricultural runoff as major contributing factors. Furthermore, it discusses the repercussions of antibiotic pollution including those relating to human health, aquatic ecosystems, and antibiotic resistance. Reviewing the causes and consequences of improper antibiotic disposal practices emphasizes the necessity of rethinking antibiotic waste management practices. The review highlights the need for stringent rules and increased awareness, while also discussing the emerging technologies and strategies to mitigate the risks of antibiotic disposal in India.

References

Anwar M, Iqbal Q, Saleem F . Improper disposal of unused antibiotics: an often overlooked driver of antimicrobial resistance. Expert Rev Anti Infect Ther. 2020; 18(8):697-699. DOI: 10.1080/14787210.2020.1754797. View

Arun S, Xin L, Gaonkar O, Neppolian B, Zhang G, Chakraborty P . Antibiotics in sewage treatment plants, receiving water bodies and groundwater of Chennai city and the suburb, South India: Occurrence, removal efficiencies, and risk assessment. Sci Total Environ. 2022; 851(Pt 2):158195. DOI: 10.1016/j.scitotenv.2022.158195. View

Barbhuiya N, Adak A . Determination of antimicrobial concentration and associated risk in water sources in West Bengal state of India. Environ Monit Assess. 2021; 193(2):77. DOI: 10.1007/s10661-020-08801-5. View

Singh Chauhan A, George M, Chatterjee P, Lindahl J, Grace D, Kakkar M . The social biography of antibiotic use in smallholder dairy farms in India. Antimicrob Resist Infect Control. 2018; 7:60. PMC: 5930822. DOI: 10.1186/s13756-018-0354-9. View

Das B, Behera B, Chakraborty H, Paria P, Gangopadhyay A, Rout A . Metagenomic study focusing on antibiotic resistance genes from the sediments of River Yamuna. Gene. 2020; 758:144951. DOI: 10.1016/j.gene.2020.144951. View

Duffy E, Ritchie S, Metcalfe S, van Bakel B, Thomas M . Antibacterials dispensed in the community comprise 85%-95% of total human antibacterial consumption. J Clin Pharm Ther. 2017; 43(1):59-64. DOI: 10.1111/jcpt.12610. View

Fick J, Soderstrom H, Lindberg R, Phan C, Tysklind M, Larsson D . Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem. 2009; 28(12):2522-7. DOI: 10.1897/09-073.1. View

Hartmann A, Golet E, Gartiser S, Alder A, Koller T, Widmer R . Primary DNA damage but not mutagenicity correlates with ciprofloxacin concentrations in German hospital wastewaters. Arch Environ Contam Toxicol. 1999; 36(2):115-9. DOI: 10.1007/s002449900449. View

Hosain M, Kabir S, Kamal M . Antimicrobial uses for livestock production in developing countries. Vet World. 2021; 14(1):210-221. PMC: 7896880. DOI: 10.14202/vetworld.2021.210-221. View

10.

Imwene K, Ngumba E, Kairigo P . Emerging technologies for enhanced removal of residual antibiotics from source-separated urine and wastewaters: A review. J Environ Manage. 2022; 322:116065. DOI: 10.1016/j.jenvman.2022.116065. View

11.

Kristiansson E, Fick J, Janzon A, Grabic R, Rutgersson C, Weijdegard B . Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements. PLoS One. 2011; 6(2):e17038. PMC: 3040208. DOI: 10.1371/journal.pone.0017038. View

12.

Larsson D, de Pedro C, Paxeus N . Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater. 2007; 148(3):751-5. DOI: 10.1016/j.jhazmat.2007.07.008. View

13.

Lubbert C, Baars C, Dayakar A, Lippmann N, Rodloff A, Kinzig M . Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens. Infection. 2017; 45(4):479-491. DOI: 10.1007/s15010-017-1007-2. View

14.

Mann A, Nehra K, Rana J, Dahiya T . Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance. Curr Res Microb Sci. 2021; 2:100030. PMC: 8610298. DOI: 10.1016/j.crmicr.2021.100030. View

15.

Mittal P, Prasoodanan Pk V, Dhakan D, Kumar S, Sharma V . Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes. Environ Microbiome. 2021; 14(1):5. PMC: 7989817. DOI: 10.1186/s40793-019-0345-3. View

16.

Phoon B, Ong C, Mohamed Saheed M, Show P, Chang J, Ling T . Conventional and emerging technologies for removal of antibiotics from wastewater. J Hazard Mater. 2020; 400:122961. DOI: 10.1016/j.jhazmat.2020.122961. View

17.

Polianciuc S, Gurzau A, Kiss B, Stefan M, Loghin F . Antibiotics in the environment: causes and consequences. Med Pharm Rep. 2020; 93(3):231-240. PMC: 7418837. DOI: 10.15386/mpr-1742. View

18.

Prabhasankar V, Joshua D, Balakrishna K, Siddiqui I, Taniyasu S, Yamashita N . Removal rates of antibiotics in four sewage treatment plants in South India. Environ Sci Pollut Res Int. 2016; 23(9):8679-85. DOI: 10.1007/s11356-015-5968-3. View

19.

Reddy B, Dubey S . River Ganges water as reservoir of microbes with antibiotic and metal ion resistance genes: High throughput metagenomic approach. Environ Pollut. 2018; 246:443-451. DOI: 10.1016/j.envpol.2018.12.022. View

20.

Singh K, Rai P, Singh A, Verma P, Gupta S . Occurrence of pharmaceuticals in urban wastewater of north Indian cities and risk assessment. Environ Monit Assess. 2014; 186(10):6663-82. DOI: 10.1007/s10661-014-3881-8. View