Inflammation Mechanism and Anti-inflammatory Therapy of Dry Eye

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Feb 29

PMID 38420354

Authors

Liyuan Chu

Caiming Wang

Hongyan Zhou

Affiliations

Soon will be listed here.

Abstract

Dry eye is a widespread chronic inflammatory disease that causes fatigue, tingling, burning, and other symptoms. Dry eye is attributed to rheumatic diseases, diabetes, hormone disorders, and contact lenses, which activate inflammatory pathways: mitogen-activated protein kinases (MAPK) and nuclear factor-B (NF-κB), promote macrophage inflammatory cell and T cell activation, and inflammation factors. Clinicians use a combination of anti-inflammatory drugs to manage different symptoms of dry eye; some of these anti-inflammatory drugs are being developed. This review introduces the dry eye inflammation mechanisms and the involved inflammatory factors. We also elucidate the anti-inflammatory drug mechanism and the detection limits.

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