Steroidal Lactones from Effectively Target Beta, Gamma, Delta and Omicron Variants of SARS-CoV-2 and Reveal a Decreased Susceptibility to Viral Infection and Perpetuation: a Polypharmacology Approach

Overview

Journal In Silico Pharmacol

Date 2024 Feb 29

PMID 38419919

Authors

Aditi Srivastava

Rumana Ahmad

Irshad A Wani

Sahabjada Siddiqui

Kusum Yadav

Anchal Trivedi

Shivbrat Upadhyay

Ishrat Husain

Tanveer Ahamad

Shivanand S Dudhagi

Affiliations

Soon will be listed here.

Abstract

Graphical Abstract:

Supplementary Information: The online version contains supplementary material available at 10.1007/s40203-023-00184-y.

References

Rodriguez Y, Rojas M, Beltran S, Polo F, Camacho-Dominguez L, Morales S . Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review. J Autoimmun. 2022; 132:102898. PMC: 9399140. DOI: 10.1016/j.jaut.2022.102898. View

Liu H, Wei P, Zhang Q, Chen Z, Aviszus K, Downing W . 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab . MAbs. 2021; 13(1):1919285. PMC: 8183533. DOI: 10.1080/19420862.2021.1919285. View

Badier L, Toledano A, Porel T, Dumond S, Jouglen J, Sailler L . IgA vasculitis in adult patient following vaccination by ChadOx1 nCoV-19. Autoimmun Rev. 2021; 20(11):102951. PMC: 8427903. DOI: 10.1016/j.autrev.2021.102951. View

Balkrishna A, Pokhrel S, Singh H, Joshi M, Mulay V, Haldar S . Withanone from Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model. Drug Des Devel Ther. 2021; 15:1111-1133. PMC: 7961299. DOI: 10.2147/DDDT.S292805. View

Patil V, Hupparage V, Malgi A, Deshpande S, Patil S, Mallapur S . Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from . Chin Herb Med. 2021; 13(3):359-369. PMC: 8222985. DOI: 10.1016/j.chmed.2021.06.002. View

Trivedi A, Ahmad R, Siddiqui S, Misra A, Khan M, Srivastava A . Prophylactic and therapeutic potential of selected immunomodulatory agents from Ayurveda against coronaviruses amidst the current formidable scenario: an analysis. J Biomol Struct Dyn. 2021; 40(20):9648-9700. DOI: 10.1080/07391102.2021.1932601. View

Liu H, Zhang Q, Wei P, Chen Z, Aviszus K, Yang J . The basis of a more contagious 501Y.V1 variant of SARS-CoV-2. Cell Res. 2021; 31(6):720-722. PMC: 8063779. DOI: 10.1038/s41422-021-00496-8. View

Srivastava A, Siddiqui S, Ahmad R, Mehrotra S, Ahmad B, Srivastava A . Exploring nature's bounty: identification of as a promising source of therapeutic agents against COVID-19 by virtual screening and evaluation. J Biomol Struct Dyn. 2020; 40(4):1858-1908. PMC: 7755033. DOI: 10.1080/07391102.2020.1835725. View

Yamamoto K . Adverse effects of COVID-19 vaccines and measures to prevent them. Virol J. 2022; 19(1):100. PMC: 9167431. DOI: 10.1186/s12985-022-01831-0. View

10.

Sinha S, Shakya A, Prasad S, Singh S, Gurav N, Prasad R . An evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets. J Biomol Struct Dyn. 2020; 39(9):3244-3255. PMC: 7232888. DOI: 10.1080/07391102.2020.1762741. View

11.

Saggam A, Limgaokar K, Borse S, Chavan-Gautam P, Dixit S, Tillu G . (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management. Front Pharmacol. 2021; 12:623795. PMC: 8126694. DOI: 10.3389/fphar.2021.623795. View

12.

Uversky V, Redwan E, Makis W, Rubio-Casillas A . IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. Vaccines (Basel). 2023; 11(5). PMC: 10222767. DOI: 10.3390/vaccines11050991. View

13.

Ibrahim T, Ismail M, Bauer M, Bekhit A, Boeckler F . Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: Methods and Benchmarking. Front Chem. 2020; 8:592289. PMC: 7674952. DOI: 10.3389/fchem.2020.592289. View

14.

Chatterjee A, Chakravarty A . Neurological Complications Following COVID-19 Vaccination. Curr Neurol Neurosci Rep. 2022; 23(1):1-14. PMC: 9707152. DOI: 10.1007/s11910-022-01247-x. View

15.

McMahon D, Amerson E, Rosenbach M, Lipoff J, Moustafa D, Tyagi A . Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. J Am Acad Dermatol. 2021; 85(1):46-55. PMC: 8024548. DOI: 10.1016/j.jaad.2021.03.092. View

16.

Wang C, Horby P, Hayden F, Gao G . A novel coronavirus outbreak of global health concern. Lancet. 2020; 395(10223):470-473. PMC: 7135038. DOI: 10.1016/S0140-6736(20)30185-9. View

17.

Siddiqui S, Upadhyay S, Ahmad R, Gupta A, Srivastava A, Trivedi A . Virtual screening of phytoconstituents from miracle herb targeting nucleocapsid protein and papain-like protease of SARS-CoV-2 for COVID-19 treatment. J Biomol Struct Dyn. 2020; 40(9):3928-3948. PMC: 7738213. DOI: 10.1080/07391102.2020.1852117. View

18.

Khanal P, Chikhale R, Dey Y, Pasha I, Chand S, Gurav N . Withanolides from as an immunity booster and their therapeutic options against COVID-19. J Biomol Struct Dyn. 2021; 40(12):5295-5308. DOI: 10.1080/07391102.2020.1869588. View

19.

McLaren J, PAPAC R . Prognosis and survival with extranodal Hodgkin's disease. J Chronic Dis. 1974; 27(9-10):447-57. DOI: 10.1016/0021-9681(74)90038-1. View

20.

Siddiqui S, Ahmad R, Alaidarous M, Zia Q, Ahmad Mir S, Alshehri B . Phytoconstituents from Moringa oleifera fruits target ACE2 and open spike glycoprotein to combat SARS-CoV-2: An integrative phytochemical and computational approach. J Food Biochem. 2022; 46(5):e14062. DOI: 10.1111/jfbc.14062. View