Mucosal-associated Invariant T Cells in Infectious Diseases of Respiratory System: Recent Advancements and Applications

Overview

Journal J Inflamm (Lond)

Publisher Biomed Central

Date 2024 Feb 28

PMID 38419084

Authors

Xue Lin

Ye Wang

Yanqi He

Affiliations

Soon will be listed here.

Abstract

Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex class I related-1 molecule (MR1). MAIT cells get activated mainly through unique TCR-dependent and TCR-independent pathways, and express multiple functional and phenotypic traits, including innate-like functionality, T helper (Th) 1 cell immunity, Th 17 cell immunity, and tissue homing. Given the functions, MAIT cells are extensively reported to play a key role in mucosal homeostasis and infectious diseases. In the current work, we review the basic characteristics of MAIT cells and their roles in mucosal homeostasis and development of respiratory infectious diseases as well as their potential therapeutic targets.

Citing Articles

Mucosal associated invariant T cells: Powerhouses of the lung.

Lopez-Rodriguez J, Barral P Immunol Lett. 2024; 269:106910.

PMID: 39128630 PMC: 11835791. DOI: 10.1016/j.imlet.2024.106910.

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