The Effect of Galantamine on Lipopolysaccharide-induced Acute Lung Injury During Neutropenia Recovery in Mice

Overview

Journal In Vivo

Specialty Oncology

Date 2024 Feb 28

PMID 38418160

Authors

Oh Beom Kwon

Wan Seo

Kyu Yean Kim

Hyonsoo Joo

Chang Dong Yeo

Jin Woo Kim

Affiliations

Soon will be listed here.

Abstract

Background/aim: Acute lung injury (ALI) is associated with a high mortality rate and cancer patients who receive chemotherapy are at high risk of ALI during neutropenia recovery. Galantamine is a cholinesterase inhibitor used for Alzheimer's disease treatment. Previous studies have shown that galantamine reduced inflammatory response in lipopolysaccharide (LPS)-induced ALI in rats. Mer protein was negatively associated with inflammatory response. The aim of the study was to investigate whether galantamine is effective in LPS-induced ALI during neutropenia recovery and its effect on Mer tyrosine kinase (MerTK) expression in mice.

Materials And Methods: Intraperitoneal cyclophosphamide was given to mice to induce neutropenia. After 7 days, LPS was administered by intratracheal instillation. Intraperitoneal galantamine was given once before LPS administration and in another group, galantamine was given twice before LPS administration.

Results: Galantamine attenuated LPS-induced ALI in histopathological analysis. The neutrophil percentage was lower in the group where galantamine was injected once, compared to the LPS group (p=0.007). MerTK expression was also higher in the group where galantamine was injected once but did not reach statistical significance (p=0.101).

Conclusion: Galantamine attenuated inflammation in LPS-induced ALI during neutropenia recovery.

Citing Articles

Ischemic Postconditioning Mitigates Lipopolysaccharide-induced Acute Lung Injury in Rats.

Serez Kaya B, Yildiz S, Ersoy O, Erge U, Tastekin E, Gunduz O In Vivo. 2024; 38(6):2705-2711.

PMID: 39477422 PMC: 11535931. DOI: 10.21873/invivo.13748.

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