Use of Statins and Risks of Ovarian, Uterine, and Cervical Diseases: a Cohort Study in the UK Biobank

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 2024 Feb 28

PMID 38416166

Authors

Xue-Feng Jiao

Hailong Li

Linan Zeng

Huazhen Yang

Yao Hu

Yuanyuan Qu

Wenwen Chen

Yajing Sun

Wei Zhang

Xiaoxi Zeng

Lingli Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: To examine the associations between use of statins and risks of various ovarian, uterine, and cervical diseases, including ovarian cancer, endometrial cancer, cervical cancer, ovarian cyst, polycystic ovarian syndrome, endometriosis, endometrial hyperplasia, endometrial polyp, and cervical polyp.

Methods: We conducted a cohort study among female participants in the UK Biobank. Information on the use of statins was collected through verbal interview. Outcome information was obtained by linking to national cancer registry data and hospital inpatient data. We used Cox proportional hazards regression to examine the associations.

Results: A total of 180,855 female participants (18,403 statin users and 162,452 non-users) were included. Use of statins was significantly associated with increased risks of cervical cancer (adjusted hazard ratio (HR), 1.55; 95% confidence interval (95% CI), 1.05-2.30) and polycystic ovarian syndrome (adjusted HR, 4.39; 95% CI, 1.68-11.49). However, we observed no significant association between use of statins and risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial hyperplasia, endometrial polyp, or cervical polyp.

Conclusion: Our findings suggest that use of statins is associated with increased risks of cervical cancer and polycystic ovarian syndrome, but is not associated with increased or decreased risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial polyp, or cervical polyp.

Citing Articles

Comment on "Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank".

Chung P, Liao K, Lai S Eur J Clin Pharmacol. 2024; 80(12):1997-1998.

PMID: 39302410 DOI: 10.1007/s00228-024-03760-z.

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