Obesity and Lung Cancer - is Programmed Death Ligand-1 (PD-1L) Expression a Connection?

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2024 Feb 28

PMID 38414472

Authors

Jakub Krzysztof Galazka

Marcin Czeczelewski

Tomasz Kucharczyk

Katarzyna Szklener

Slawomir Mandziuk

Affiliations

Soon will be listed here.

Abstract

Introduction: In this retrospective study, the authors evaluated whether obesity-induced immunomodulation impacts the expression of programmed death ligand-1 (PD-1L) in lung cancer cells.Methods: A retrospective cross-sectional study was performed. The study included 67 patients. The data did not have a normal distribution.

Results: For women, using ANOVA test ( = 0.050) with post-hoc analysis, a statistically significant difference in expression was found between women with overweight and women with normal weight ( = 0.040).

Conclusions: Apart from the above, the authors did not find any statistically significant correlation between PD-1L expression on lung cancer cells and body mass index, either in the whole group or in histological subgroups.

Citing Articles

The Impact of Metabolic and Bariatric Surgery on Apo B100 Levels in Individuals with high BMI: A Multi-Centric Prospective Cohort Study.

Jaliliyan A, Madankan A, Mosavari H, Khalili P, Pouraskari B, Lotfi S Obes Surg. 2024; 34(7):2454-2466.

PMID: 38744799 DOI: 10.1007/s11695-024-07258-6.

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