Plasticity of Gene Expression in the Nervous System by Exposure to Environmental Odorants That Inhibit HDACs

Overview

Journal Elife

Specialty Biology

Date 2024 Feb 27

PMID 38411140

Authors

Sachiko Haga-Yamanaka

Rogelio Nunez-Flores

Christi A Scott

Sarah Perry

Stephanie Turner Chen

Crystal Pontrello

Meera G Nair

Anandasankar Ray

Affiliations

Soon will be listed here.

Abstract

Eukaryotes respond to secreted metabolites from the microbiome. However, little is known about the effects of exposure to volatiles emitted by microbes or in the environment that we are exposed to over longer durations. Using we evaluated a yeast-emitted volatile, diacetyl, found at high levels around fermenting fruits where they spend long periods of time. Exposure to the diacetyl molecules in headspace alters gene expression in the antenna. experiments demonstrated that diacetyl and structurally related volatiles inhibited conserved histone deacetylases (HDACs), increased histone-H3K9 acetylation in human cells, and caused changes in gene expression in both and mice. Diacetyl crosses the blood-brain barrier and exposure caused modulation of gene expression in the mouse brain, therefore showing potential as a neuro-therapeutic. Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a neuroblastoma cell line in culture. Exposure to diacetyl vapors slowed progression of neurodegeneration in a model for Huntington's disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on histone acetylation, gene expression, and physiology in animals.

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PMID: 39373630 PMC: 11458174. DOI: 10.7554/eLife.96445.

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