Giant Cell Tumor of the Frontal Bone: A Rare Case Report and Review of Literature

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Feb 26

PMID 38406073

Authors

Mohammed Ar Abdellatif

Karam Rabi

Ahmed T Ghanem

Ahmed Dawoud

Izzeddin A Bakri

Affiliations

Soon will be listed here.

Abstract

Giant cell tumors (GCTs), typically benign, predominantly manifest in individuals aged 20-40, with the most common locations being the metaphysis or epiphysis of the femur or tibia. Infrequently, they may occur in the skull. Despite their benign nature, these tumors can exhibit aggressive behavior and have the potential to metastasize. In the case at hand, a 20-year-old female presented to the hospital with a progressively enlarging right frontal swelling over the preceding months. The patient reported intermittent headaches, alleviated by analgesics, and exhibited a normal neurological examination along with a Glasgow Coma Scale (GCS) score of 15 out of 15. Imaging revealed an expansive soft tissue mass in the right frontal bone involving both inner and outer tables. Surgical intervention was pursued through a right frontal incision followed by tumor excision. Histopathological examination of the specimen confirmed the presence of a GCT. The limited existing literature on this topic highlights the need for further research and insights into effective strategies. This case contributes to addressing this gap in knowledge, offering valuable information to enhance our understanding of the challenges associated with similar rare cases and improve patient outcomes.

References

Wang H, Wan N, Hu Y . Giant cell tumour of bone: a new evaluating system is necessary. Int Orthop. 2012; 36(12):2521-7. PMC: 3508056. DOI: 10.1007/s00264-012-1664-9. View

Jadidi S, DAbarno A, Barkley J, Abusuwwa R . Giant Cell Tumor of the Frontal Bone: A Case Report and Literature Review. Cureus. 2018; 10(9):e3353. PMC: 6255713. DOI: 10.7759/cureus.3353. View

Mavrogenis A, Igoumenou V, Megaloikonomos P, Panagopoulos G, Papagelopoulos P, Soucacos P . Giant cell tumor of bone revisited. SICOT J. 2017; 3:54. PMC: 5598212. DOI: 10.1051/sicotj/2017041. View

Kattner K, Stroink A, Gupta K, Fukushima T, Li C . Giant cell tumor of the sphenoid bone. Skull Base Surg. 2006; 8(2):93-7. PMC: 1656693. DOI: 10.1055/s-2008-1058582. View

Osaka S, Toriyama S . Surgical treatment of giant cell tumors of the pelvis. Clin Orthop Relat Res. 1987; (222):123-31. View

Huang L, Xu J, Wood D, Zheng M . Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. Am J Pathol. 2000; 156(3):761-7. PMC: 1876848. DOI: 10.1016/s0002-9440(10)64942-5. View

Bridge J, Neff J, Mouron B . Giant cell tumor of bone. Chromosomal analysis of 48 specimens and review of the literature. Cancer Genet Cytogenet. 1992; 58(1):2-13. DOI: 10.1016/0165-4608(92)90125-r. View

Divisato G, Scotto di Carlo F, Pazzaglia L, Rizzo R, Coviello D, Benassi M . The distinct clinical features of giant cell tumor of bone in pagetic and non-pagetic patients are associated with genetic, biochemical and histological differences. Oncotarget. 2017; 8(38):63121-63131. PMC: 5609908. DOI: 10.18632/oncotarget.18670. View

Domovitov S, Healey J . Primary malignant giant-cell tumor of bone has high survival rate. Ann Surg Oncol. 2009; 17(3):694-701. DOI: 10.1245/s10434-009-0803-z. View

10.

Larsson S, Lorentzon R, Boquist L . Giant-cell tumor of bone. A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968. J Bone Joint Surg Am. 1975; 57(2):167-73. View

11.

Harris A, Beckner M, Barnes L, Kassam A, Horowitz M . Giant cell tumor of the skull: a case report and review of the literature. Surg Neurol. 2004; 61(3):274-7. DOI: 10.1016/S0090-3019(03)00428-2. View

12.

Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G . Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008; 134(9):969-78. DOI: 10.1007/s00432-008-0370-x. View

13.

Viswanathan S, Jambhekar N . Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities?. Clin Orthop Relat Res. 2009; 468(3):827-33. PMC: 2816751. DOI: 10.1007/s11999-009-0966-8. View

14.

Freeman J, Oushy S, Schowinsky J, Sillau S, Youssef A . Invasive Giant Cell Tumor of the Lateral Skull Base: A Systematic Review, Meta-Analysis, and Case Illustration. World Neurosurg. 2016; 96:47-57. DOI: 10.1016/j.wneu.2016.05.086. View

15.

Sobti A, Agrawal P, Agarwala S, Agarwal M . Giant Cell Tumor of Bone - An Overview. Arch Bone Jt Surg. 2016; 4(1):2-9. PMC: 4733230. View

16.

Anract P, De Pinieux G, Cottias P, Pouillart P, Forest M, Tomeno B . Malignant giant-cell tumours of bone. Clinico-pathological types and prognosis: a review of 29 cases. Int Orthop. 1998; 22(1):19-26. PMC: 3619644. DOI: 10.1007/s002640050201. View