Evaluation of a Novel Tc-24 Recombinant Antigen ELISA for Serologic Testing for in Dogs

Overview

Journal bioRxiv

Date 2024 Feb 26

PMID 38405948

Authors

Rojelio Mejia

Guilherme G Verocai

Ilana A Mosley

Bin Zhan

Lindsey Vongthavaravat

Rachel E Busselman

Sarah A Hamer

Affiliations

Soon will be listed here.

Abstract

Chagas disease is a parasitic infection caused by . Diagnosis of chronic Chagas disease in dogs relies on limited serological test options. This study used a new Tc-24 recombinant antigen ELISA on an archival set of 70 dog serum samples from multi-dog kennel environments in Texas subjected to three existing Chagas serological tests. Tc-24 ELISA produced a quantitative result and could detect anti- antibodies in dogs with high sensitivity and specificity. Comparing individual tests to Tc-24 ELISA resulted in strong associations and correlations, which suggest that Tc-24 ELISA is a reliable and accurate diagnostic tool for dogs with a single test.

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