Feasibility of Identifying Factors Related to Alzheimer's Disease and Related Dementia in Real-World Data

Overview

Journal medRxiv

Date 2024 Feb 26

PMID 38405723

Authors

Aokun Chen

Qian Li

Yu Huang

Yongqiu Li

Yu-Neng Chuang

Xia Hu

Serena Guo

Yonghui Wu

Yi Guo

Jiang Bian

Affiliations

Soon will be listed here.

Abstract

A comprehensive view of factors associated with AD/ADRD will significantly aid in studies to develop new treatments for AD/ADRD and identify high-risk populations and patients for prevention efforts. In our study, we summarized the risk factors for AD/ADRD by reviewing existing meta-analyses and review articles on risk and preventive factors for AD/ADRD. In total, we extracted 477 risk factors in 10 categories from 537 studies. We constructed an interactive knowledge map to disseminate our study results. Most of the risk factors are accessible from structured Electronic Health Records (EHRs), and clinical narratives show promise as information sources. However, evaluating genomic risk factors using RWD remains a challenge, as genetic testing for AD/ADRD is still not a common practice and is poorly documented in both structured and unstructured EHRs. Considering the constantly evolving research on AD/ADRD risk factors, literature mining via NLP methods offers a solution to automatically update our knowledge map.

References

Oliveira D, Bosco A, Di Lorito C . Is poor health literacy a risk factor for dementia in older adults? Systematic literature review of prospective cohort studies. Maturitas. 2019; 124:8-14. DOI: 10.1016/j.maturitas.2019.03.010. View

Wylegala A . Principles of OCTA and Applications in Clinical Neurology. Curr Neurol Neurosci Rep. 2018; 18(12):96. PMC: 6209039. DOI: 10.1007/s11910-018-0911-x. View

Sommer I, Griebler U, Kien C, Auer S, Klerings I, Hammer R . Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis. BMC Geriatr. 2017; 17(1):16. PMC: 5237198. DOI: 10.1186/s12877-016-0405-0. View

The Lancet . Lecanemab for Alzheimer's disease: tempering hype and hope. Lancet. 2022; 400(10367):1899. DOI: 10.1016/S0140-6736(22)02480-1. View

Resciniti N, Tang W, Tabassum M, Pearson J, Spencer S, Lohman M . Knowledge evaluation instruments for dementia caregiver education programs: A scoping review. Geriatr Gerontol Int. 2020; 20(5):397-413. PMC: 7748382. DOI: 10.1111/ggi.13901. View

Collingridge Moore D, Keegan T, Dunleavy L, Froggatt K . Factors associated with length of stay in care homes: a systematic review of international literature. Syst Rev. 2019; 8(1):56. PMC: 6381725. DOI: 10.1186/s13643-019-0973-0. View

Saini R, Rengasamy K, Mahomoodally F, Keum Y . Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives. Pharmacol Res. 2020; 155:104730. DOI: 10.1016/j.phrs.2020.104730. View

Hua Y, Guo X, Huang Q, Kong Y, Lu X . Association between interleukin-6 -174G/C polymorphism and the risk of Alzheimer's disease: a meta-analysis. Int J Neurosci. 2013; 123(9):626-35. DOI: 10.3109/00207454.2013.784286. View

Karlsson W, Sorensen C, Kruuse C . l-arginine and l-NMMA for assessing cerebral endothelial dysfunction in ischaemic cerebrovascular disease: A systematic review. Clin Exp Pharmacol Physiol. 2016; 44(1):13-20. DOI: 10.1111/1440-1681.12679. View

10.

Theoharides T, Tsilioni I . Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases. Curr Top Med Chem. 2018; 18(21):1872-1882. DOI: 10.2174/1568026617666181119154247. View

11.

Oudman E, Wijnia J, van Dam M, Biter L, Postma A . Preventing Wernicke Encephalopathy After Bariatric Surgery. Obes Surg. 2018; 28(7):2060-2068. PMC: 6018594. DOI: 10.1007/s11695-018-3262-4. View

12.

Rochoy M, Rivas V, Chazard E, Decarpentry E, Saudemont G, Hazard P . Factors Associated with Alzheimer's Disease: An Overview of Reviews. J Prev Alzheimers Dis. 2019; 6(2):121-134. DOI: 10.14283/jpad.2019.7. View

13.

Shen L, Ji H . Associations between Homocysteine, Folic Acid, Vitamin B12 and Alzheimer's Disease: Insights from Meta-Analyses. J Alzheimers Dis. 2015; 46(3):777-90. DOI: 10.3233/JAD-150140. View

14.

Ford A, Almeida O . Pharmacological interventions for preventing delirium in the elderly. Maturitas. 2015; 81(2):287-92. DOI: 10.1016/j.maturitas.2015.03.024. View

15.

Yates L, Ziser S, Spector A, Orrell M . Cognitive leisure activities and future risk of cognitive impairment and dementia: systematic review and meta-analysis. Int Psychogeriatr. 2016; 28(11):1791-1806. DOI: 10.1017/S1041610216001137. View

16.

Liang Y, Wang L . Alzheimer's Disease is an Important Risk Factor of Fractures: a Meta-analysis of Cohort Studies. Mol Neurobiol. 2016; 54(5):3230-3235. DOI: 10.1007/s12035-016-9841-2. View

17.

Lanctot K, Rajaram R, Herrmann N . Therapy for Alzheimer's Disease: How Effective are Current Treatments?. Ther Adv Neurol Disord. 2010; 2(3):163-80. PMC: 3002627. DOI: 10.1177/1756285609102724. View

18.

Angehrn Z, Sostar J, Nordon C, Turner A, Gove D, Karcher H . Ethical and Social Implications of Using Predictive Modeling for Alzheimer's Disease Prevention: A Systematic Literature Review. J Alzheimers Dis. 2020; 76(3):923-940. DOI: 10.3233/JAD-191159. View

19.

Stephan B, Birdi R, Tang E, Cosco T, Donini L, Licher S . Secular Trends in Dementia Prevalence and Incidence Worldwide: A Systematic Review. J Alzheimers Dis. 2018; 66(2):653-680. DOI: 10.3233/JAD-180375. View

20.

Devi Bastida J, Genesca Pujol J, Valle Vives S, Jofre Font S, Fetscher Eickhoff A, Arroyo Cardona E . Disorder of the personality: a possible factor of risk for the dementia. Actas Esp Psiquiatr. 2019; 47(2):61-9. View