Polypyrimidine Tract-binding Protein 3/insulin-like Growth Factor 2 MRNA-binding Proteins 3/high-mobility Group A1 Axis Promotes Renal Cancer Growth and Metastasis

Overview

Journal iScience

Publisher Cell Press

Date 2024 Feb 26

PMID 38405614

Authors

Qianqing Wang

Fang Chen

Yu He

Yue Gao

Jiawen Wang

Sufang Chu

Pei Xie

Jiateng Zhong

Haixia Shan

Jin Bai

Pingfu Hou

Affiliations

Soon will be listed here.

Abstract

Polypyrimidine tract-binding protein 3 (PTBP3) plays an important role in the post-transcriptional regulation of gene expression, including mRNA splicing, translation, and stability. Increasing evidence has shown that PTBP3 promotes cancer progression in several tumor types. However, the molecular mechanisms of PTBP3 in renal cell carcinoma (RCC) remain unknown. Here, tissue microarrays (TMAs) suggested that PTBP3 expression was increased in human RCC and that high PTBP3 expression was correlated with poor five-year overall survival and disease-free survival. We also showed that PTBP3 binds with HMGA1 mRNA in the 3'UTR region and let-7 miRNAs. PTBP3 interacted with IGF2BP3, and the PTBP3/IGF2BP3 axis prevented let-7 mediated HMGA1 mRNA silencing. PTBP3 promotes renal cancer cell growth and metastasis and . Taken together, our findings indicate PTBP3 serves as a regulator of HMGA1 and suggest its potential as a therapeutic agent for RCC.

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