Autopsy of Drug-induced Lung Injury with Atypical Diffuse Alveolar Disorder Due to Amiodarone

Overview

Journal Intern Med

Specialty General Medicine

Date 2024 Feb 25

PMID 38403765

Authors

Hikaru Mamizu

Hiroki Kohda

Yuusuke Tomita

Takuma Hatakeyama

Maiko Mamizu

Daisuke Ishikawa

Hidenori Kawakami

Toshiki Furukawa

Takashi Ishida

Tsuyoshi Sakai

Affiliations

Soon will be listed here.

Abstract

Amiodarone, a prominent antiarrhythmic drug, may cause lung injury. We herein report the case of an 87-year-old man who had been taking amiodarone for 5 years and was subsequently referred due to respiratory failure. Chest computed tomography revealed multiple consolidations with air bronchograms in both lungs. Despite administering steroid pulse therapy, his respiratory failure worsened, and he died 3 days later. Autopsy revealed hyaline membrane formation and organic formation with fibrin deposition. Drug-induced lung injury caused by amiodarone was confirmed by autopsy. Caution is therefore required when fibrin deposition in the alveolar spaces is observed in such cases, which are prone to suffer a rapid deterioration.

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