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Organ Selectivity of Hexahydrosiladifenidol in Blocking Pre- and Postjunctional Muscarinic Receptors Studied in Guinea-pig Ileum and Rat Heart

Overview
Journal Eur J Pharmacol
Specialty Pharmacology
Date 1985 Jul 11
PMID 3840090
Citations 18
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Abstract

Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is concluded that pre- and postjunctional muscarinic receptors in the heart may differ from those in the ileum.

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