Diversity and Structure of Genes of the Alpha Family of Mouse T-cell Antigen Receptor

Overview

Journal Nature

Specialty Science

Date 1985 Aug 4

PMID 3839904

Citations 87

Authors

B Arden

J L Klotz

G Siu

L E HOOD

Affiliations

Soon will be listed here.

Abstract

We have analysed 19 complementary DNA clones encoding the alpha-chain of the T-cell antigen receptor derived from thymic transcripts, and find that 15 of them contain partial or complete variable (V alpha) genes. Seven of these genes cross-hybridize to over 40 germline V alpha gene segments in Southern blot analyses. Of the 19 joining (J alpha) sequences examined, 18 seem to be encoded by distinct gene segments, hence the repertoire of J alpha gene segments is much larger than those of the immunoglobulin or T-cell receptor beta-chain gene families. We suggest that the variable domains of immunoglobulins and T-cell antigen receptors are similar in structure.

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