B Cells Dynamic in Aging and the Implications of Nutritional Regulation

Overview

Journal Nutrients

Date 2024 Feb 24

PMID 38398810

Authors

Yifei Yu

Chenxu Lu

Weiru Yu

Yumei Lei

Siyuan Sun

Ping Liu

Feirong Bai

Yu Chen

Juan Chen

Affiliations

Soon will be listed here.

Abstract

Aging negatively affects B cell production, resulting in a decrease in B-1 and B-2 cells and impaired antibody responses. Age-related B cell subsets contribute to inflammation. Investigating age-related alterations in the B-cell pool and developing targeted therapies are crucial for combating autoimmune diseases in the elderly. Additionally, optimal nutrition, including carbohydrates, amino acids, vitamins, and especially lipids, play a vital role in supporting immune function and mitigating the age-related decline in B cell activity. Research on the influence of lipids on B cells shows promise for improving autoimmune diseases. Understanding the aging B-cell pool and considering nutritional interventions can inform strategies for promoting healthy aging and reducing the age-related disease burden.

Citing Articles

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References

Nguyen C, Kim H, Cornelius J, Peck A . Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3. J Immunol. 2007; 179(4):2318-29. PMC: 2850056. DOI: 10.4049/jimmunol.179.4.2318. View

Winer D, Winer S, Shen L, Wadia P, Yantha J, Paltser G . B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011; 17(5):610-7. PMC: 3270885. DOI: 10.1038/nm.2353. View

Frasca D, Landin A, Lechner S, Ryan J, Schwartz R, Riley R . Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol. 2008; 180(8):5283-90. DOI: 10.4049/jimmunol.180.8.5283. View

Naradikian M, Myles A, Beiting D, Roberts K, Dawson L, Herati R . Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells. J Immunol. 2016; 197(4):1023-8. PMC: 4975960. DOI: 10.4049/jimmunol.1600522. View

Corneth O, Verstappen G, Paulissen S, de Bruijn M, Rip J, Lukkes M . Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease. Arthritis Rheumatol. 2017; 69(6):1313-1324. DOI: 10.1002/art.40059. View

Sacco K, Abraham R . Consequences of B-cell-depleting therapy: hypogammaglobulinemia and impaired B-cell reconstitution. Immunotherapy. 2018; 10(8):713-728. DOI: 10.2217/imt-2017-0178. View

Fasano S, Isenberg D . Present and novel biologic drugs in primary Sjögren's syndrome. Clin Exp Rheumatol. 2019; 37 Suppl 118(3):167-174. View

Qi T, Sun M, Zhang C, Chen P, Xiao C, Chang X . Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation. Cell Rep. 2020; 33(9):108452. DOI: 10.1016/j.celrep.2020.108452. View

Bag-Ozbek A, Hui-Yuen J . Emerging B-Cell Therapies in Systemic Lupus Erythematosus. Ther Clin Risk Manag. 2021; 17:39-54. PMC: 7814238. DOI: 10.2147/TCRM.S252592. View

10.

Lenert P, Brummel R, Field E, Ashman R . TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production. J Clin Immunol. 2005; 25(1):29-40. DOI: 10.1007/s10875-005-0355-6. View

11.

Yousefzadeh M, Flores R, Zhu Y, Schmiechen Z, Brooks R, Trussoni C . An aged immune system drives senescence and ageing of solid organs. Nature. 2021; 594(7861):100-105. PMC: 8684299. DOI: 10.1038/s41586-021-03547-7. View

12.

Lee J, Park H, Lim J, Jin H, Park Y, Jung Y . GSK3 Restrains Germinal Center B Cells to Form Plasma Cells. J Immunol. 2020; 206(3):481-493. DOI: 10.4049/jimmunol.2000908. View

13.

Guo J, Gu M, Zhang W, Liu Y, Qian C, Deng A . Aberrant IL-35 levels in patients with primary Sjogren's syndrome. Scand J Immunol. 2018; 88(5):e12718. DOI: 10.1111/sji.12718. View

14.

Szabo K, Papp G, Szanto A, Tarr T, Zeher M . A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjögren's syndrome and systemic lupus erythematosus. Clin Exp Immunol. 2015; 183(1):76-89. PMC: 4687513. DOI: 10.1111/cei.12703. View

15.

Barber C, Montecino-Rodriguez E, Dorshkind K . Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A. 2011; 108(33):13700-4. PMC: 3158209. DOI: 10.1073/pnas.1107172108. View

16.

Phalke S, Marrack P . Age (autoimmunity) associated B cells (ABCs) and their relatives. Curr Opin Immunol. 2018; 55:75-80. DOI: 10.1016/j.coi.2018.09.007. View

17.

Harvey P, Gordon C . B-cell targeted therapies in systemic lupus erythematosus: successes and challenges. BioDrugs. 2013; 27(2):85-95. DOI: 10.1007/s40259-013-0015-8. View

18.

Lopez-Santalla M, Fernandez-Perez R, Garin M . Mesenchymal Stem/Stromal Cells for Rheumatoid Arthritis Treatment: An Update on Clinical Applications. Cells. 2020; 9(8). PMC: 7465092. DOI: 10.3390/cells9081852. View

19.

Navarini L, Afeltra A, Gallo Afflitto G, Margiotta D . Polyunsaturated fatty acids: any role in rheumatoid arthritis?. Lipids Health Dis. 2017; 16(1):197. PMC: 5634864. DOI: 10.1186/s12944-017-0586-3. View

20.

Jin R, Kaneko H, Suzuki H, Arai T, Teramoto T, Fukao T . Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. Int J Mol Med. 2008; 21(2):233-8. View