The Association of Gene Polymorphisms with the Risk of Coronary Artery Disease Occurrence and Cardiovascular Survival in the Polish Population: A Case-Control and a Prospective Cohort Study

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Feb 24

PMID 38396951

Authors

Joanna Iwanicka

Anna Balcerzyk-Matic

Tomasz Iwanicki

Katarzyna Mizia-Stec

Pawel Banka

Artur Filipecki

Katarzyna Gawron

Alicja Jarosz

Tomasz Nowak

Jolanta Krauze

Pawel Niemiec

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate whether the polymorphisms of the gene affect the risk of occurrence and mortality due to CAD. The study group included 231 patients diagnosed with CAD and 240 control blood donors. The genotyping of specified polymorphisms, i.e., rs1994016, rs3825807, and rs7173743, was performed using the TaqMan-PCR. We found that the C allele carriers of the rs1994016 and A allele carriers of the rs3825807 polymorphisms increased the risk of CAD, respectively: OR = 1.72, = 0.036; OR = 1.64, = 0.04. Moreover, we studied the biological interactions of specified variants, i.e., rs3825807, rs1994016, and rs7173743, and previously approved risk factors of CAD. We demonstrated here that selected polymorphisms of increased the risk of CAD altogether with abnormalities of total cholesterol and LDL concentrations in serum. Although survival analyses did not reveal statistical significance, we observed a trend for the AA genotype of the rs3825807 , which may predispose to death due to CAD in a 5-year follow-up. In conclusion, the polymorphisms investigated in this study may increase the risk of occurrence and/or death due to CAD in the Polish population.

Citing Articles

The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?.

Pietruszynska-Reszetarska A, Pietruszynski R, Irzmanski R Int J Mol Sci. 2024; 25(13).

PMID: 39000032 PMC: 11241586. DOI: 10.3390/ijms25136924.

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