Improved Graft Function Following Desensitization of Anti-ATR and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Feb 24

PMID 38396895

Authors

Regina Jung

Kevin Ly

Michiko Taniguchi

Aileen Grace Arriola

Christopher Gravante

Derek Shinn

Leena Mathew

Eman Hamad

Steven Geier

Abdelhamid Liacini

Affiliations

Soon will be listed here.

Abstract

HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for ATR is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

Citing Articles

Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation - Is It Time to Test?.

Martin P, Willicombe M, Roufosse C Transpl Int. 2024; 37:13280.

PMID: 39606688 PMC: 11598415. DOI: 10.3389/ti.2024.13280.

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