» Articles » PMID: 38396876

Flagella

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2024 Feb 24
PMID 38396876
Authors
Affiliations
Soon will be listed here.
Abstract

is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors. But the dysbiosis of the intestinal microbiota creating the conditions for the colonization appears to be fundamental for our understanding of the disease. Colonization implies several steps for the bacteria that do or do not use their capacity of motility with the synthesis of flagella. In this review, we focus on the current understanding of different topics on the flagellum, ranging from its genetic organization to the vaccinal interest in it.

References
1.
Ternan N, Jain S, Srivastava M, McMullan G . Comparative transcriptional analysis of clinically relevant heat stress response in Clostridium difficile strain 630. PLoS One. 2012; 7(7):e42410. PMC: 3408451. DOI: 10.1371/journal.pone.0042410. View

2.
McKee R, Mangalea M, Purcell E, Borchardt E, Tamayo R . The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigD. J Bacteriol. 2013; 195(22):5174-85. PMC: 3811590. DOI: 10.1128/JB.00501-13. View

3.
Hensbergen P, de Ru A, Friggen A, Corver J, Smits W, Van Veelen P . New insights into the type A glycan modification of Clostridioides difficile flagellar protein flagellin C by phosphoproteomics analysis. J Biol Chem. 2022; 298(3):101622. PMC: 8861647. DOI: 10.1016/j.jbc.2022.101622. View

4.
Chandrasekaran R, Lacy D . The role of toxins in Clostridium difficile infection. FEMS Microbiol Rev. 2017; 41(6):723-750. PMC: 5812492. DOI: 10.1093/femsre/fux048. View

5.
Delmee M, Avesani V, Delferriere N, Burtonboy G . Characterization of flagella of Clostridium difficile and their role in serogrouping reactions. J Clin Microbiol. 1990; 28(10):2210-4. PMC: 268149. DOI: 10.1128/jcm.28.10.2210-2214.1990. View