High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, As Well As on Calcium Metabolism Abnormalities

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2024 Feb 24

PMID 38396434

Authors

Dominique Israel-Biet

Nicol Bernardinello

Jean Pastre

Claudio Tana

Paolo Spagnolo

Affiliations

Soon will be listed here.

Abstract

Although sarcoidosis is generally regarded as a benign condition, approximately 20-30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liver and/or kidneys representing additional life-threatening situations. In this review, we discuss diagnosis and treatment of each of these complications and highlight how the integration of clinical, pathological and radiological features may help predict the development of such high-risk situations in sarcoid patients.

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