Identification of Serotonin M-receptor Subtypes and Their Specific Blockade by a New Class of Drugs

Overview

Journal Nature

Specialty Science

Date 1985 Jul 11

PMID 3839291

Citations 193

Authors

B P Richardson

G Engel

P Donatsch

P A Stadler

Affiliations

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Abstract

We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.

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