Clinical Outcome of Multiple Platelet-Rich Plasma Injection and Correlation with PDGF-BB in the Treatment of Knee Osteoarthritis

Overview

Journal J Pers Med

Date 2024 Feb 23

PMID 38392616

Authors

Radiyati Umi Partan

Khoirun Mukhsinin Putra

Hafizzanovian Hafizzanovian

Surya Darma

Muhammad Reagan

Putri Muthia

Afifah Salshabila Radiandina

Eny Rahmawati

Affiliations

Soon will be listed here.

Abstract

(1) Background: Current treatments for knee osteoarthritis (KOA), such as intra-articular corticosteroids or hyaluronic acid (HA) injections, are controversial due to their ineffectiveness in preventing disease progression. Platelet-rich plasma (PRP) has become a promising and possible treatment for KOA. It is thought to enhance articular cartilage regeneration and reduce OA-related impairment. PRP contains growth factors such as PDGF-BB, which stimulates growth and inhibits joint damage. Based on numerous studies, after a certain amount of time, it was found that multiple PRP treatments reduced pain more than a single injection. This study evaluates the efficacy of multiple PRP (m-PRP) injections compared to multiple HA (m-HA) injections for KOA treatment, focusing on their correlation with PDGF-BB levels. (2) Methods: In this single-center, open-label, randomized, comparative clinical trial, 30 KOA patients received m-PRP and m-HA injections. VAS and WOMAC were used to evaluate clinical outcomes and PDGF-BB concentrations. (3) Results: The study analysis revealed a statistically significant reduction in pain indices. In both the m-PRP and m-HA groups after 12 weeks, m-PRP showed superior results. PDGF-BB concentrations also increased, with a strong negative correlation and statistical significance using Spearman's rho. (4) Conclusions: Multiple PRP injections are safe and associated with elevated PDGF-BB, reduced VAS and WOMAC scores, providing the potential for articular cartilage regeneration and inhibiting knee osteoarthritis progression.

Citing Articles

Optimal Dosage of Platelet-Rich Plasma Injections in Patients With Osteoarthritis of the Knee: A Scoping Review.

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PMID: 39803130 PMC: 11717558. DOI: 10.7759/cureus.75497.

Efficacy of Platelet-Rich Plasma Intra-articular Injections in Hip and Knee Osteoarthritis.

Shahbaz A, Alzarooni A, Veeranagari V, Patel K, Mohammed C, Kuruba V Cureus. 2024; 16(9):e69656.

PMID: 39429381 PMC: 11488654. DOI: 10.7759/cureus.69656.

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