Gut-Microbiome Implications in Opioid Use Disorder and Related Behaviors

Overview

Journal Adv Drug Alcohol Res

Specialty Psychiatry

Date 2024 Feb 23

PMID 38390617

Authors

Bridget Herlihy

Sabita Roy

Affiliations

Soon will be listed here.

Abstract

Substance use disorder (SUD) is a prevalent disease that has caused hundreds of thousands of deaths and affected the lives of even more. Despite its global impact, there is still no known cure for SUD, or the psychological symptoms associated with drug use. Many of the behavioral consequences of drug use prevent people from breaking the cycle of addiction or cause them to relapse back into the cycle due to the physical and psychological consequences of withdrawal. Current research is aimed at understanding the cause of these drug related behaviors and therapeutically targeting them as a mechanism to break the addiction cycle. Research on opioids suggests that the changes in the microbiome during drug use modulated drug related behaviors and preventing these microbial changes could attenuate behavioral symptoms. This review aims to highlight the relationship between the changes in the microbiome and behavior during opioid treatment, as well as highlight the additional research needed to understand the mechanism in which the microbiome modulates behavior to determine the best therapeutic course of action.

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References

Sullivan R, Duchesne A, Hussain D, Waldron J, Laplante F . Effects of unilateral amygdala dopamine depletion on behaviour in the elevated plus maze: role of sex, hemisphere and retesting. Behav Brain Res. 2009; 205(1):115-22. DOI: 10.1016/j.bbr.2009.07.023. View

Lach G, Schellekens H, Dinan T, Cryan J . Anxiety, Depression, and the Microbiome: A Role for Gut Peptides. Neurotherapeutics. 2017; 15(1):36-59. PMC: 5794698. DOI: 10.1007/s13311-017-0585-0. View

Vuong H, Yano J, Fung T, Hsiao E . The Microbiome and Host Behavior. Annu Rev Neurosci. 2017; 40:21-49. PMC: 6661159. DOI: 10.1146/annurev-neuro-072116-031347. View

Kelly J, Kennedy P, Cryan J, Dinan T, Clarke G, Hyland N . Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci. 2015; 9:392. PMC: 4604320. DOI: 10.3389/fncel.2015.00392. View

Lyte M, Varcoe J, Bailey M . Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiol Behav. 1998; 65(1):63-8. DOI: 10.1016/s0031-9384(98)00145-0. View

Xiao H, Ge C, Feng G, Li Y, Luo D, Dong J . Gut microbiota modulates alcohol withdrawal-induced anxiety in mice. Toxicol Lett. 2018; 287:23-30. PMC: 5912338. DOI: 10.1016/j.toxlet.2018.01.021. View

Thomas D, Walker P, Benjamins J, Geddes T, Kuhn D . Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. J Pharmacol Exp Ther. 2004; 311(1):1-7. DOI: 10.1124/jpet.104.070961. View

Bravo J, Forsythe P, Chew M, Escaravage E, Savignac H, Dinan T . Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011; 108(38):16050-5. PMC: 3179073. DOI: 10.1073/pnas.1102999108. View

Banerjee S, Sindberg G, Wang F, Meng J, Sharma U, Zhang L . Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation. Mucosal Immunol. 2016; 9(6):1418-1428. PMC: 4996771. DOI: 10.1038/mi.2016.9. View

10.

OSullivan S, Malahias E, Park J, Srivastava A, Reyes B, Gorky J . Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis. Front Neurosci. 2019; 13:665. PMC: 6619439. DOI: 10.3389/fnins.2019.00665. View

11.

Keshavarzian A, Farhadi A, Forsyth C, Rangan J, Jakate S, Shaikh M . Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol. 2009; 50(3):538-47. PMC: 2680133. DOI: 10.1016/j.jhep.2008.10.028. View

12.

Wang F, Meng J, Zhang L, Johnson T, Chen C, Roy S . Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. Sci Rep. 2018; 8(1):3596. PMC: 5827657. DOI: 10.1038/s41598-018-21915-8. View

13.

Bonaz B, Bazin T, Pellissier S . The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018; 12:49. PMC: 5808284. DOI: 10.3389/fnins.2018.00049. View

14.

Park A, Collins J, Blennerhassett P, Ghia J, Verdu E, Bercik P . Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil. 2013; 25(9):733-e575. PMC: 3912902. DOI: 10.1111/nmo.12153. View

15.

Neufeld K, Kang N, Bienenstock J, Foster J . Effects of intestinal microbiota on anxiety-like behavior. Commun Integr Biol. 2011; 4(4):492-4. PMC: 3181531. DOI: 10.4161/cib.4.4.15702. View

16.

Sommer F, Backhed F . The gut microbiota--masters of host development and physiology. Nat Rev Microbiol. 2013; 11(4):227-38. DOI: 10.1038/nrmicro2974. View

17.

Xu Y, Xie Z, Wang H, Shen Z, Guo Y, Gao Y . Bacterial Diversity of Intestinal Microbiota in Patients with Substance Use Disorders Revealed by 16S rRNA Gene Deep Sequencing. Sci Rep. 2017; 7(1):3628. PMC: 5472629. DOI: 10.1038/s41598-017-03706-9. View

18.

Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K . Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. 2020; 7(3). PMC: 7242819. DOI: 10.1523/ENEURO.0312-19.2020. View

19.

Meng J, Banerjee S, Li D, Sindberg G, Wang F, Ma J . Opioid Exacerbation of Gram-positive sepsis, induced by Gut Microbial Modulation, is Rescued by IL-17A Neutralization. Sci Rep. 2015; 5:10918. PMC: 4454150. DOI: 10.1038/srep10918. View

20.

Mello B, Monte A, McIntyre R, Soczynska J, Custodio C, Cordeiro R . Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration. J Psychiatr Res. 2013; 47(10):1521-9. DOI: 10.1016/j.jpsychires.2013.06.008. View