Chromosomes of Human Sperm: Variability Among Normal Individuals

Overview

Journal Hum Genet

Specialty Genetics

Date 1985 Jan 1

PMID 3838965

Citations 36

Authors

B Brandriff

L Gordon

L Ashworth

G Watchmaker

D Moore 2nd

A J Wyrobek

A V Carrano

Affiliations

Soon will be listed here.

Abstract

The chromosomal constitution of 2468 human sperm cells has been investigated by fusion of human sperm with hamster eggs. The overall frequency of cells with structural aberrations was 7.7%, ranging from 1.9% to 15.8%, and varying significantly among individuals. The highest frequency occurred in sperm from the oldest donor (49 years), who also had had a vasectomy reversal three years prior to sampling. The overall aneuploidy frequency was 1.7%, ranging from 0.6% to 3.1%. In nine out of ten donors from whom blood samples were available the frequency of sperm cells with structural aberrations was higher than that for lymphocytes. Two previously reported donors (Brandriff et al. 1984) were resampled after an interval of 14 and 16 months respectively, and were each found to have similar frequencies of sperm chromosome abnormalities at both sampling times. A father-son pair included in the study had several chromosome breakpoints in common, although no more frequently than unrelated individuals.

Citing Articles

Sperm and Oocyte Chromosomal Abnormalities.

Samura O, Nakaoka Y, Miharu N Biomolecules. 2023; 13(6).

PMID: 37371589 PMC: 10296299. DOI: 10.3390/biom13061010.

Comprehensive chromosome FISH assessment of sperm aneuploidy in normozoospermic males.

Zhu S, Zhu Y, Zhang F, Wu J, Lei C, Jiang F J Assist Reprod Genet. 2022; 39(8):1887-1900.

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Lack of trusted diagnostic tools for undetermined male infertility.

Pandruvada S, Royfman R, Shah T, Sindhwani P, Dupree J, Schon S J Assist Reprod Genet. 2021; 38(2):265-276.

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Meiotic susceptibility for induction of sperm with chromosomal aberrations in patients receiving combination chemotherapy for Hodgkin lymphoma.

Frias S, Van Hummelen P, Meistrich M, Wyrobek A PLoS One. 2020; 15(12):e0242218.

PMID: 33370316 PMC: 7769287. DOI: 10.1371/journal.pone.0242218.

Chromosomal integrity and DNA damage in freeze-dried spermatozoa.

Kusakabe H Reprod Med Biol. 2018; 10(4):199-210.

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